DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gria2 and Ir64a

DIOPT Version :9

Sequence 1:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	128/717 - (17%)
Similarity:	235/717 - (32%)	Gaps:	218/717 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse   315 RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQN-----GKRI----N 370
            |.|..|.|.:.:.|:  .....|.||.::.........:|...|.:....|     .||:    :
  Fly   196 RTQTAEGSGKRDDGE--MEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAH 258

Mouse   371 YTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT-------------------- 415
            ||  :.::...|....|:        |.|||:.|...|.|::..|
  Fly   259 YT--LFDVWNPGLNYGGH--------VNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVR 313

Mouse   416 --VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT------IVGDGKYG 472
              ||||....:..:|....|.|....:....:..:|...:.....:.:.|:      .|.:|::
  Fly   314 CMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVKNGRF- 377

Mouse   473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS 537
                     :||:|.|:..:.||..||:...|.|.:.||.:....|.....:.:.|:.::.....
  Fly   378 ---------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIV 433

Mouse   538 FLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW----------------------------- 572
            ||.|...::|:.||    |..|: :|::...:..||
  Fly   434 FLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQ 494

Mouse   573 ------------------------HTEEFEDG----------------------RETQSSESTNE 591
                                    ..||:||.                      |:.:..::...
  Fly   495 EQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPER 559

Mouse   592 FGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655
            .|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:|: ...|:
  Fly   560 VGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK-PKTIK 623

Mouse   656 SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVA-------- 712
            :..|| ..:.:..|..|....:::|..:|..|..:::     |:....|.||.|..|
  Fly   624 TLSDL-VHSSLKVGMEDILYNRDYFLHTKDPVSMELY-----AKKITSVPTTKENEADEDEPVDP 682

Mouse   713 ------------RVRKSKGKYAYLLESTMNEYIE-----------------------------QR 736
                        .:..|....|:..::..:.:::                             ::
  Fly   683 NPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQ 747

Mouse   737 KPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGS 801
            ..||..:|......|...| ..|.|.:|..::..:.:::|.|:|....|.|...|..|     ..
  Fly   748 DICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPC-----VK 806

Mouse   802 KEKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKMTLSAATRNKARLSITG 864
            |.:||.|  .:..|:....||:....:.:::...|..|              :...|:.:|...|
  Fly   807 KIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY--------------SKWHNRIQLKWVG 857

Mouse   865 ST 866
            :|
  Fly   858 AT 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	17/91 (19%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	90/534 (17%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/127 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	54/277 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840