DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADRA1A and adra1a

DIOPT Version :9

Sequence 1:	NP_150646.3	Gene:	ADRA1A / 148	HGNCID:	277	Length:	475	Species:	Homo sapiens
Sequence 2:	XP_002933012.2	Gene:	adra1a / 100492776	XenbaseID:	XB-GENE-6048410	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	440	Identity:	297/440 - (67%)
Similarity:	353/440 - (80%)	Gaps:	6/440 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVFLSGNASDSS-----NCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
            ||.|..|.:..|     |||.|.|.:||||||::|||.|..|.|||||||||||||||||||.:|
Frog    20 MVILYENNTVESIQLCLNCTHPGATINISKAIVVGVIFGVFITFGVLGNILVILSVACHRHLQTV 84

Human    61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRY 125
            |||:|.|||||||||.|.||||||.||:.|||.|||:||||||||||||||||||.||.||||||
Frog    85 THYFIANLAVADLLLMSMVLPFSATFEIQGYWLFGRIFCNIWAAVDVLCCTASIMSLCAISIDRY 149

Human   126 IGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSAL 190
            ||||||||||:|:|::||::||||:|.|||||||||||||:||||||:.||:|.:||||.||||.
Frog   150 IGVSYPLRYPSIMTEKRGVLALLCIWVLSLVISIGPLFGWKQPAPEDDKICEITKEPGYALFSAF 214

Human   191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
            |||||||:||||||.|||:||||||:.|.||:|.:|||||:||||||||:.|......:|:|.||
Frog   215 GSFYLPLSIILVMYFRVYIVAKRESKVLTSGMKLEKSDSEEVTLRIHRKSTPESIGSTSSSKQKT 279

Human   256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSC 320
            .||||||||||||||||||||||||||||||||||||||||.:|....|:|:|||.|||||.|||
Frog   280 QFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIYPPANSSDTIFKITFWLGYFNSC 344

Human   321 INPIIYPCSSQEFKKAFQNVLRIQCLCRKQ-SSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRET 384
            |||:||||||.||:|||||:|..:|..|:| :||::.|:.|:.|......::|::|||||||.|.
Frog   345 INPVIYPCSSPEFRKAFQNILHARCSHRRQAASKYSSGFLLNSPVHRSSEENKNVVRIPVGSGEM 409

Human   385 FYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLEC 434
            ||||||:|..||||:|:.:|..:......:|.::|::||..|:|..|..|
Frog   410 FYRISKSDEGCEWKYFTPLPSPATPYGTPRDFANCSSARVSSKSFLRTCC 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRA1A	NP_150646.3	7tm_4	37..341	CDD:304433	238/303 (79%)
		7tm_1	43..326	CDD:278431	220/282 (78%)
		Nuclear localization signal	334..349		7/14 (50%)
adra1a	XP_002933012.2	7tmA_alpha1A_AR	51..361	CDD:320448	239/309 (77%)
		TM helix 1	52..78	CDD:320448	19/25 (76%)
		TM helix 2	85..111	CDD:320448	20/25 (80%)
		TM helix 3	123..153	CDD:320448	27/29 (93%)
		TM helix 4	165..188	CDD:320448	17/22 (77%)
		TM helix 5	205..234	CDD:320448	24/28 (86%)
		TM helix 6	289..319	CDD:320448	29/29 (100%)
		TM helix 7	329..354	CDD:320448	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	472	1.000	Domainoid score	I4279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68078
Inparanoid	1	1.050	655	1.000	Inparanoid score	I5814
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43807
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	1	1.000	-	-		oto151579
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080