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Protein Alignment Gria1 and GluRIA

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	971	Identity:	380/971 - (39%)
Similarity:	549/971 - (56%)	Gaps:	131/971 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 IQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYA 84
            |.:|.:|........:||::|     |:..:...:|...:|::|.:|:|:::...|:|||:|||:
  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104

Mouse    85 IFGFYERRTVNMLTSFCGALHVCFITPSFP----VDTSN--QFVLQLRPELQEALISIIDHYKWQ 143
            :.|.....:.:.|.|:.....:.|:||.||    ..:|.  .|.:.:||:..:|:|..|.:|.||
  Fly   105 MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQ 169

Mouse   144 TFVYIYDADRGLSVLQRVLDTAAEKN--WQVTAVNILTTTEEGYRML--FQDLEKKKERLVVVDC 204
            :.:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:..::.:|:||
  Fly   170 SIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234

Mouse   205 ESERLNAILGQIVKLEKNG-IGYHYILANLGFMD----IDLNKFKESGA-NVTGFQLVNYTDTIP 263
            .:|....|:.|.|:..|.| ..|||:|:.| .||    .|:.:|   || |:|||::|:..
  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGL-VMDNHWPSDVVEF---GAINITGFRIVDSN---- 291

Mouse   264 ARIMQQWRTSDARDHTRVDWKRPKYT-------------SALTYDGVKVMAEAFQSLRRQRID-- 313
            .|.::.:.  |:|.......:.....             :||.||.|.|:.|||..:.|::.|
  Fly   292 RRAVRDFH--DSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQF 354

Mouse   314 ----ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRFEGLTGNVQFN 356
                :.||.:.|                ||..:.  ..||.||..|.|.|::|..:||:|.::|:
  Fly   355 RSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFD 419

Mouse   357 EKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFVPAATDAQAGGDNSSV-------QNRTYIVTT 413
            |.|||.||||||:||. :..::::..|.:|...:|..:...|....|:.       :|.||||::
  Fly   420 EDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSS 484

Mouse   414 ILEDPYVMLKK--NANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTK-AWN 475
            :||:||:.||:  ......||||:||||.:||..:|..:|..|.:.:|.||.|||.:.... .|:
  Fly   485 LLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWD 549

Mouse   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 540
            ||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||
  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW 614

Mouse   541 MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQ---------------------SNE 584
            :.::.:|:|||.||:.|:||.||||..  ....:..:|:.|                     .||
  Fly   615 ISVILSYVGVSFVLYFVTRFPPYEWRI--VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE 677

Mouse   585 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649
            |.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::
  Fly   678 FTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKT 742

Mouse   650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY 714
            .|||..||::.||||..|||.||||||:|.:..|||.|| :|.....|.|.:||:.|||:|||||
  Fly   743 PEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKY 806

Mouse   715 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSK 779
            |.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.|||.|.|.|.|.::::|
  Fly   807 ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871

Mouse   780 WWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCL 844
            ||:||.||......|  ..:.||||||||::|||||||.||::||::||             ||
  Fly   872 WWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------------FC- 920

Mouse   845 IPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGAT 905
                      |..| |:....|::|.:| |..|.:.|..:.:...|...|...:.:.:.|:
  Fly   921 ----------RNKT-PQLKSPGSNGSAG-GVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.