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Protein Alignment Gria1 and GluRIIB

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	247/872 - (28%)
Similarity:	409/872 - (46%)	Gaps:	100/872 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 IQIGGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIF 86
            |:||.:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.|||
  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIF 89

Mouse    87 GFYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRPE---LQEALISII-- 137
            |...:..   |.:|.:..|..|:.|   .:....||      |..:.:.|.   |..|...|:
  Fly    90 GPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS 151

Mouse   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERLV 200
            ..:.|::|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.|
  Fly   152 KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKFV 212

Mouse   201 VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAR 265
            ::||.|:.|..::...:.....|...|..|.||   |..|       :.:.||...::|..:.|.
  Fly   213 LLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAAV 267

Mouse   266 IMQQWRTSDARDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLA 325
            .::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:.
  Fly   268 RIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIP 323

Mouse   326 NPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380
            |.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..|
  Fly   324 NFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI- 385

Mouse   381 YWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN--Q 428
             ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...  .
  Fly   386 -WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVH 445

Mouse   429 FEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPL 493
            :|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..|
  Fly   446 YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDL 510

Mouse   494 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 558
            |||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....
  Fly   511 TITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTG 575

Mouse   559 RFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 623
            |...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|.
  Fly   576 RIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFA 637

Mouse   624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYM 688
            |:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..|
  Fly   638 LLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKM 702

Mouse   689 KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG 753
            .|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|..
  Fly   703 LSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLN 766

Mouse   754 SALRGPVNLAVLKLSEQGVLDKLKSKWW-YDKGECGSK----DSGSKDKTSALSLSNVAGVFYIL 813
            :..|..:::.:|:|||:|.|.||::||: .::..|.|.    |.|..|      :.:|.|:|.:|
  Fly   767 ADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFD------MDSVGGLFVVL 825

Mouse   814 IGGLGLAMLVALIEFCYKSRSESKRMK 840
            |.|:.:.:::.:.||.:..:..|.:.|
  Fly   826 IVGVVVGLVIGVAEFLWHVQRISVKEK 852

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.