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Protein Alignment Gria1 and GluRIIA

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	942	Identity:	273/942 - (28%)
Similarity:	465/942 - (49%)	Gaps:	114/942 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 IFAF-FCTGFLGAVV--GANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNI- 64
            |:|| ...|||..::  |.:..|.|.:|.:|...:.:...:|..|..::..  ....::..|.|
  Fly     8 IYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNN--MKFSELRFVTIK 70

Mouse    65 -----SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT------S 118
                 :|||.:....|...|.||.||||...:...:::.....|..:..|.....::.      :
  Fly    71 RYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135

Mouse   119 NQFVLQLRPE---LQEALISII-DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILT 179
            :|..:.:.|.   |..|...|| .:|:|:||..||:...||:.||.:::..|..:..|...|:..
  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLAD 200

Mouse   180 TTEEGYRMLFQDLEKK-KERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANL-----GFMDI 238
            ..:: ||:|:::.::. .|:.:::|||.:.|..:|...:..:..|...::.|.:|     |..||
  Fly   201 YADD-YRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDI 264

Mouse   239 DLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYT--SALTYDGVKVMA 301
            ....||   ||:|..:|    ..:.|...::.:|.    .|:||......|  ..|.||.|.:
  Fly   265 YNEDFK---ANITSVRL----KVVDANPFERKKTR----LTKVDQILGNQTMLPILIYDAVVL-- 316

Mouse   302 EAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL-----TGNVQFNEKGRR 361
              |.|..|..|...:..:..:.....:.||..|..|...::.:..:.:     |.|::.:|.|:|
  Fly   317 --FASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQR 379

Mouse   362 TNYTLHV----------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILE 416
            .::.|.:          :....:||:|        :.:....::.....:.|.|.:.|.|.|..|
  Fly   380 IHFNLEIYKPTVNEPMMVWTPDNGIKK--------RLLNLELESAGTTQDFSEQRKVYTVVTHYE 436

Mouse   417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVS-DGKYGARDPDTKAWNGMVGE 480
            :||.|:|::...|.|.::||||.|:|.:::::.:.:.|...||: :|||   :|:||.|:|::.:
  Fly   437 EPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGIIRK 498

Mouse   481 LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVF 545
            |:...|.:.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|:.::|
  Fly   499 LIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIF 563

Mouse   546 AYIGVSVVLFLVSRFSPYEW--------HSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQG 602
            |.:.:::....::|.|..||        ..:|.|           |.:.:.||.|..:|:.||||
  Fly   564 AQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----------NIWNVNNSTWLMVGSIMQQG 617

Mouse   603 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAG 667
            |||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|
  Fly   618 CDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGG 682

Mouse   668 STKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPC 732
            ||..||..|....:::.|..||...||.|..|.:||:.||||.||.||:|:|:|...|..:|. |
  Fly   683 STSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-C 746

Mouse   733 DTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKG-ECGSKDSGSKD 796
            |..::|..:..|.||:|.|.||..|..:::::|:|||:|.|.|:|:|||.:.. .|.|......|
  Fly   747 DLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD 811

Mouse   797 KTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSI----------- 850
            :   ||:..:.|||.:|.||:.:.:::.:.||.:..::.:...:   :.|.|:.
  Fly   812 E---LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEER---VTPWQAFKAELIFALKFW 870

Mouse   851 --NEAIRTSTLPRNSGAGASGGS--GSGENGR 878
              .:.:|.|:....|.:..|.||  .|.|..|
  Fly   871 VRKKPMRISSSSDKSSSRRSSGSRRSSKEKSR 902

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.