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Protein Alignment Gria1 and Ir25a

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	986	Identity:	255/986 - (25%)
Similarity:	419/986 - (42%)	Gaps:	269/986 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 GFLGAV------VGANFPNNIQIGGLFPNQQSQEHAA-------------FRFALSQLTEPPKLL 56
            |||..:      :.|....||.:  ||.|:...|.||             .|:.||
  Fly    16 GFLSLLSSFSLEIAAQTTQNINV--LFINEVDNEPAAKAVEVVLTYLKKNIRYGLS--------- 69

Mouse    57 PQIDIV--NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNML-------------TSFCGALHV 106
            .|:|.:  |.||:..:....|::::..:      .:::|.:::             .||..||.:
  Fly    70 VQLDSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGL 128

Mouse   107 CFITPSF----------PVDTSNQ-FVLQLRPE---LQEALISIIDHYKWQTFVYIYDAD----- 152
            ..|:.|:          .:|.:.| ::||:.|.   :.||:.||:.|........:||..
  Fly   129 PTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDH 193

Mouse   153 RGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCES-------ERLN 210
            :..|:||.:     :....:||:     .::|.|    :.|::.|:|..:|..:       :.:.
  Fly   194 KYKSLLQNI-----QTRHVITAI-----AKDGKR----EREEQIEKLRNLDINNFFILGTLQSIR 244

Mouse   211 AILGQI--VKLEKNGIGYHYILANLG--------------------------------------- 234
            .:|..:  ...|:| ..:|.|..|.|
  Fly   245 MVLESVKPAYFERN-FAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEP 308

Mouse   235 ------FMDIDLNKF---KE---SGANVTGFQLVNYTDTIPARIMQQWRTSDARDH-TRVDWKRP 286
                  :.|:.|..|   ||   |||.....:.:|..|.......|  |..|.||: |::    .
  Fly   309 QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQ--RNLDLRDYFTKI----T 367

Mouse   287 KYTSALTYDGVKVMAEAF--QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL 349
            :.||..|:|.|....:.|  .|..:..:||:                         :.|:|
  Fly   368 EPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN-------------------------VLQIR---- 403

Mouse   350 TGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT----YI 410
             |....|.|                   .||.|      :..........|...::|.|    |.
  Fly   404 -GGSSVNSK-------------------SIGKW------ISGLNSELIVKDEEQMKNLTADTVYR 442

Mouse   411 VTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475
            :.|:::.|::|..:.|.:     .|:|||::|..|||..|.:.|.::.|.|||:|..| :...||
  Fly   443 IFTVVQAPFIMRDETAPK-----GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWN 501

Mouse   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEI 539
            |:|.:|:..:||:.:..:::...||.||||:.|:..| ||:||:::| .|...:|.||..|...:
  Fly   502 GIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNV 565

Mouse   540 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 604
            |:||:.||...|.::::..|:|||.:.:.. |:.:|   .::..||.:...|||.:.:...||..
  Fly   566 WLCILAAYFFTSFLMWIFDRWSPYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGG 626

Mouse   605 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 669
            .:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|...|.
  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691

Mouse   670 KEFF--------------------------RRSKIAVFE--------KMWTYMKSAE-PSVFVRT 699
            ..:|                          .|||:||::        |||..|:.|: |:    |
  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----T 752

Mouse   700 TEEGMIRVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNL 762
            .:|.:.|||.|...  :|:|.::|...|: |...||...||.....|.|.||..:||.|:...|.
  Fly   753 LDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNN 816

Mouse   763 AVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE 827
            |:|.|..:..|:|||.||| ...|..:|....:|::..:|:.|:.|||.::..|:|:|.:..:.|
  Fly   817 AILTLLNKRQLEKLKEKWW-KNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFE 880

Mouse   828 F-CYKSRSESK 837
            : .|:.|...:
  Fly   881 YWWYRYRKNPR 891

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.