DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gria1 and GluRIIC

DIOPT Version :9

Sequence 1:NP_001106796.1 Gene:Gria1 / 14799 MGIID:95808 Length:907 Species:Mus musculus
Sequence 2:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster


Alignment Length:957 Identity:267/957 - (27%)
Similarity:429/957 - (44%) Gaps:122/957 - (12%)


- Green bases have known domain annotations that are detailed below.


Mouse    13 LGAVVGANF-----PNNIQIGGLFPNQQSQEHAAFRFALSQLTEPP-----KLLPQIDIVNISD- 66
            ||.:..|.|     ...|.||..|.:.:.:....|...::.:..|.     :..|.|..:...| 
  Fly     8 LGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDG 72

Mouse    67 SFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS----------NQF 121
            |..|....|.....||.||||...:...:::...|.:..:    |....|.|          :|.
  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHIEFDISDEGIQAEKPNHQM 133

Mouse   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDAD--RGLSVLQRVLDTAAEKNWQVTAVNILTTT 181
            .|.|.|.   |.:|...|:.::.|:.|..:||||  |..:.||.:|......| .|..|... ..
  Fly   134 TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-DVVRVRKF-HK 196

Mouse   182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKF--- 243
            ::.:|::::.:  :.||.||:|||...|..:|....:....|...|..|.||......|.:.   
  Fly   197 DDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259

Mouse   244 -KESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYT--SALTYDGVKVMAEAFQ 305
             :....|:|..:|:...|..|..:...:.|.  ||:...:...|..|  ..|.:|.:::.|::::
  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVTQ--RDNIVYESSDPPRTLIHDLIHDALQLFAQSWR 322

Mouse   306 S---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------QVRFEGLTGNVQFNEKGRR 361
            :   ....|:.:.|  ...|..|:....|..|..:.|.::      ...|.  |..:||:|.|:|
  Fly   323 NASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFR--TSILQFDEDGQR 383

Mouse   362 TNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA 426
            ..:.:.|.: ..||| .|..|:      |.....|...|..:.:...|.|.|.:..||....:.|
  Fly   384 ITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETA 440

Mouse   427 NQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVA 489
            .:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:||.|||::||::...|.:.
  Fly   441 RELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMG 505

Mouse   490 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 554
            :..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.
  Fly   506 ICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMT 567

Mouse   555 FL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 616
            ||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.|..||||.|||...|:..
  Fly   568 FLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFE 629

Mouse   617 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVF 681
            ..||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||......|...|:
  Fly   630 ATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVY 694

Mouse   682 EKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGY 746
            ...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:.:.||...||.....|.|
  Fly   695 RLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHY 758

Mouse   747 GIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYD-KGECGSKDSGSKDKTSALSLSNVAGVF 810
            .||.|.|:..|..:::|:|||||:|.|..||.|||.: ...|  .:....|.|..::...:.|:|
  Fly   759 AIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASC--FEEPDPDATPDMTFEELRGIF 821

Mouse   811 YILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL------------------ 844
            |.|..|:.:|.|:.:.||             .:|...:.:.....|:                  
  Fly   822 YTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRT 886

Mouse   845 IPQQSINEAI-------------RTSTLPRNSGAGASGGSGSGENGR 878
            .|::|:::::             |:|...|....|:...|||...||
  Fly   887 TPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Gria1NP_001106796.1 PBP1_iGluR_AMPA_GluR1 26..389 CDD:107385 90/398 (23%)
ANF_receptor 37..372 CDD:279440 82/370 (22%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 144/386 (37%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)
Lig_chan 538..817 CDD:278489 102/282 (36%)