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Protein Alignment Gria1 and GluRIIE

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	859	Identity:	291/859 - (33%)
Similarity:	446/859 - (51%)	Gaps:	86/859 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 VGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLL--PQIDI---------------VNI 64
            :..|:......|| :.|.||.|.........|.||...::  ..||:               ||.
  Fly    17 ISVNWAQYENFGG-YDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVNY 80

Mouse    65 SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRP-E 128
            .|:::...:.|.....|:..:||...|.|...|.|.|.|:.:..|. |:..:.:..|.|...| :
  Fly    81 GDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPAD 144

Mouse   129 LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLE 193
            |.:||.|:|..:.|..|:::|::...|::|..:.....:....:|.:.........|:.:.:.:.
  Fly   145 LAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVR 209

Mouse   194 KKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNY 258
            |..:..:||...||.:...|.|..::......|.||:.||.|...||.::|.|.||:||.:|.:.
  Fly   210 KSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSP 274

Mouse   259 TDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDC 323
            .......::.:......:|..|..........|||||.|::.|:..::|
  Fly   275 EKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL---------------- 323

Mouse   324 LANPAVPWGQGIDIQRALQQVRFEG----------------LTGNVQFNEKGRRTNYTLHVIEMK 372
               |..|..|... ||. :.||.:|                |||.:.| |...|..|.|.|||::
  Fly   324 ---PFKPMPQNCS-QRT-ESVRDDGSSFKNYMRTLRLTDRLLTGPIYF-EGNVRKGYHLDVIELQ 382

Mouse   373 HDGIRKIGYWNEDDKFVP---AATDAQAGGDNSSVQNRTYIV-TTILEDPYVMLKKNANQFEGND 433
            ..||.|:|.|:||.::.|   |.|.||....::|:.|:|:|: .::...||..|.:...|.|||.
  Fly   383 PSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNS 447

Mouse   434 RYEGYCVELAAEIAKHVGYSYRLEIVSDGK-YGARDPDTKAWNGMVGELVYGRADVAVAPLTITL 497
            :||||.|:|..|:|..:|:::  ..|:.|. ||:.:..|....||:.|::.||||:|:..||||.
  Fly   448 QYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITS 510

Mouse   498 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 562
            .||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||
  Fly   511 EREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSP 575

Mouse   563 YEWHS-----EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 622
            .||.:     ||.||        ..|:|.:.||:||:.||.:|||.:|.|::||.|.|...||||
  Fly   576 SEWDNPYPCIEEPEE--------LENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFF 632

Mouse   623 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLEAGSTKEFFRRSKIAVFEKMWT 686
            |||::||||||||||||:|:..|.|.|.:|||...: :.||..:.|||:.||..|....::||..
  Fly   633 TLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNK 697

Mouse   687 YMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATP 751
            :| |..|........||:.|| |:...||:|:|||..||..:|: |:..|:|..||.||||||..
  Fly   698 FM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMR 759

Mouse   752 KGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGE--CGSKDSGSKDKTSALSLSNVAGVFYILI 814
            |....||..|.|:|:|.|||||:|:|:|||.:.|.  |.:|:. :.|.| .|.::|:.|||::|:
  Fly   760 KDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKED-APDAT-PLDMNNLEGVFFVLL 822

Mouse   815 GGLGLAMLVALIEF 828
            .|...|:|..:|.:
  Fly   823 VGSCCALLYGIISW 836

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.