DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gria1 and Ir7a

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	168	Identity:	35/168 - (20%)
Similarity:	64/168 - (38%)	Gaps:	56/168 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse   151 ADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQ 215
            |:| |.||:.:..|..  .:..:.|.:||...:|..:::      ..||:.:||:   |:..| :
  Fly   137 AER-LQVLRDISRTCV--RFHTSNVILLTEKRDGVVLVY------AYRLLNMDCD---LSVNL-E 188

Mouse   216 IVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQW---------- 270
            ::.:.|||:..|                   |.....|..|......|.::  .|
  Fly   189 LIDIYKNGLFRH-------------------GHEARSFNRVLSLSGCPLQV--SWYPLPPFVSFI 232

Mouse   271 -RTSDARDHTRVDWKRPKYTSALT-YDG--VKVMAEAF 304
             .:||..:..:: |:       || .||  :|::|..|
  Fly   233 GNSSDPEERAQI-WR-------LTGIDGELIKLLASIF 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_001106796.1	PBP1_iGluR_AMPA_GluR1	26..389	CDD:107385	35/168 (21%)
		ANF_receptor	37..372	CDD:279440	35/168 (21%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447
		Glutamate binding. /evidence=ECO:0000250	492..494
		Lig_chan	538..817	CDD:278489
		Glutamate binding. /evidence=ECO:0000250	668..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir7a	NP_572406.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810