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Protein Alignment Gria1 and Nmdar2

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	208/924 - (22%)
Similarity:	355/924 - (38%)	Gaps:	208/924 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 FPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSK-GVYAI--------F 86
            |....|.|.....|.:..||..|..:              ....|.:|.: .|.||        |
  Fly   138 FLKDYSFEQKNIHFDMMSLTPSPTAI--------------LSTLCKEFLRVNVSAILYMMNNEQF 188

Mouse    87 GFYERRTVNMLTSFCGALHVCFITPSFPVDTS--------NQFVLQLRPELQE---ALISIIDHY 140
            | :...:........|.|.:..|  |:..|.|        :...|||.|.::.   |::||::.|
  Fly   189 G-HSTASAQYFLQLAGYLGIPVI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250

Mouse   141 KWQTFVYIYDADRGL-SVLQRVLDTAAE--KNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV 202
            ||..|..:.....|. ..:|.|.:..||  ::::.|.:|.:..|.....|   :|...:.|::::
  Fly   251 KWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---ELVNSEARVMLL 312

Mouse   203 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIM 267
            .........||....:::..|..|.::::.      .:.:.|::.:......|..:.||..|.:|
  Fly   313 YATQTEAITILRAAEEMKLTGENYVWVVSQ------SVIEKKDAHSQFPVGMLGVHFDTSSAALM 371

Mouse   268 QQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMA---EAF--------QSLRRQRIDISRRGNAG 321
            .:  .|:|                     :|:.:   ||:        :.|..|.:.....|..
  Fly   372 NE--ISNA---------------------IKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG- 412

Mouse   322 DCLANPAVPWGQGIDIQRALQQVRFEGLTG--NVQFNEKGRRTNYTLHVIEMKHDGIRK------ 378
                    .|..|....:.|:.|..||...  |::|...|...:..|.::.::.....|
  Fly   413 --------RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEE 469

Mouse   379 IGYWN--EDDKF------VPAATDAQAGGDNSSVQNRTYIVTTILED-PYVMLKK---------- 424
            ||.|.  |..|.      .|..:.|...|    |..:.::..|.||: ||:.|..
  Fly   470 IGVWKSWETQKLDIRDIAWPGNSHAPPQG----VPEKFHLKITFLEEAPYINLSPADPVSGKCLM 530

Mouse   425 ------------------NANQFEGNDRY----EGYCVELAAEIAKHVGYSYRLEIVSDGKYGAR 467
                              :..|...|:.:    .|:|::|..:.|:.:|::|.|..|.|||:|..
  Fly   531 DRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL 595

Mouse   468 DPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS-- 530
              :...|||::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|
  Fly   596 --ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPT 654

Mouse   531 -FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRD-----QTTSDQSNEFGIF 588
             ||:|.....||.: :.|....:.::||      :||.|   ..|.|     |.|:.....|.:|
  Fly   655 AFLEPFDTASWMLVGIVAIQAATFMIFL------FEWLS---PSGYDMKLYLQNTNVTPYRFSLF 710

Mouse   589 NSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTV 640
            .:.|.......|....: |||..:.|.:..||..|.::.::.||||||||            |..
  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775

Mouse   641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMI 705
            .|:|.|      .:.:....:||:....|.....:    .|..|..||:....:    :..:|:.
  Fly   776 SRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNKT----SVADGVA 826

Mouse   706 RVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSE 769
            .|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:...
  Fly   827 AVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890

Mouse   770 QGVLDKLKSKWWYDKGEC--GSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE---FC 829
            .|.|::|:..|.  .|.|  |.::..|.|   .|:|......|.:|:.|:.||.|:.|:|   |.
  Fly   891 NGDLERLRRYWM--TGTCRPGKQEHKSSD---PLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950

Mouse   830 YKSRSESKRMKGFC 843
            |..:..:|:..|.|
  Fly   951 YIRKRLAKKDGGHC 964

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.