DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF582 and sqz

DIOPT Version :9

Sequence 1:	NP_001307300.2	Gene:	ZNF582 / 147948	HGNCID:	26421	Length:	517	Species:	Homo sapiens
Sequence 2:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	98/359 - (27%)
Similarity:	148/359 - (41%)	Gaps:	109/359 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   148 EMPT--------------FDQHAS---LTFYQKIHTREKPFGYNKCRK------DFWQKELLINH 189
            |:||              .||..|   ||..|.:|. .|||..::.|:      |:..|..|:.|
  Fly     3 ELPTAPNGVPSGDYLHRSIDQLRSLGHLTTAQLVHD-YKPFNISEFRQNVAERLDYSLKNGLVQH 66

Human   190 -QGIYTNEKPYKCKECGKAFKYGSRLIQHENIH-------------------SGKKPYECKE--- 231
             |.:...::|:..::            |.:::|                   |...|:|.:|
  Fly    67 QQQMVMEQQPHPDQQ------------QQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQKY 119

Human   232 ----------CGKAFNSGSNFI---QHQRVHTGE--KPYECKDCEKAFSRSSQLIEHQRTHTGEK 281
                      ...|..||||..   :..|...|:  |||:|..|.|:|:.||.|.:|.|.|.|.|
  Fly   120 DPNRSPPRQQMSSASGSGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIK 184

Human   282 PYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHTGRKLYECKECGK 346
            ||:|:.|.:.|.::|||:.|.|.|||:|||.|:..|                          |.|
  Fly   185 PYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAG--------------------------CPK 223

Human   347 AFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQRIHTGE---KPYQCKVCGRAFKRVS 408
            ||:|.|.|..|.|.|..:||::|..|.|.|.....|.:|...|...   |.:.|.:||:::.:.:
  Fly   224 AFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQET 288

Human   409 HLTVHYRIHTGEKPYECKECGKAFSHCSQLIHHQ 442
            :|..|.:.| .||..:     :...|.:|:..||
  Fly   289 YLQKHLQKH-AEKAEK-----QQHRHTAQVAAHQ 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF582	NP_001307300.2	None
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	9/19 (47%)
		zf-H2C2_2	172..197	CDD:290200	11/24 (46%)
		zf-C2H2	186..208	CDD:278523	9/21 (43%)
		C2H2 Zn finger	188..208	CDD:275368	8/19 (42%)
		zf-C2H2_8	191..271	CDD:292531	34/105 (32%)
		zf-H2C2_2	200..227	CDD:290200	16/52 (31%)
		C2H2 Zn finger	216..238	CDD:275368	11/47 (23%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010