Protein Alignment Grb7 and pico

DIOPT Version :10

• Sequence 1: NP_034476.1
• Gene: Grb7 / 14786
• MGIID: 102683
• Length: 535
• Species: Mus musculus
• Sequence 2: NP_608363.1
• Gene: pico / 33003
• FlyBaseID: FBgn0261811
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 125/507 - (24%)
• Similarity: 193/507 - (38%)
• Gaps: 120/507 - (23%)

Mouse    34 PPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCS----------------------- 75
            ||||.:.....|.:.:.|:.|.|.      |...:.|.:..|
  Fly   244 PPPGGMTMGITLGVVTPREPRTES------PDNDSAFSDTVSLLSSESSASSNTSLQQQQQQQQQ 302

Mouse    76 ------------PPSQKPILGGS----------------SGARGLLPRDSSRLCV---------- 102
                        ...|||.|.|:                |||..:...|..:|.:
  Fly   303 QHHQHQQHHQHQQQQQKPQLAGAEKLHHHGVHGQHGGQQSGANSITKADKIQLALHKLESAPIRR 367

Mouse   103 --VKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDESWGLVESHPYLALERGLEDHEFVVE 165
              ||.::.|||.:|:.|.......||..:|..:.|.....:|.|||....|.:||..||||.:|:
  Fly   368 LFVKAFTSDGASKSLLVDERMGCGHVTRLLADKNHVQMQSNWALVEHLGDLQMERLFEDHELLVD 432

Mouse   166 VQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCL-DAQTGISHEDLIQNFLNAGSFP 229
            ....|.....:|.:|::...|..||..|...|...:|...|. |.||   .:.|:..|.::.:..
  Fly   433 NLMTWHSDAGNRVLFQQRPDKVTLFLRPELYLPGPQMAPGCQHDEQT---RQMLLDEFFDSHNQL 494

Mouse   230 EIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRK 294
            ::.|.|.:    :...:|.|||:...||.|||||..|..:|:.|.|..:...:..|||.....||
  Fly   495 QMDGPLYM----KADPKKGWKRYHFVLRSSGLYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRK 555

Mouse   295 LYGMPTD--FGF-CVKPNKLRNGHKGLHIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 356
            .:..|||  ||| .|..:.|....:.|.:.|:||..:...||.|.|:.|||.||:.::
  Fly   556 KWKSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSH------- 613

Mouse   357 LRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIDNPREALSAAMEEAQAWRKKTNHRLS--LPTTC 419
                       :|:.::..::.|             :|:|.: ..|.:.|.::...:|  :|:.|
  Fly   614 -----------KSLLEDLCLSRD-------------DAVSQS-SFAASMRSESISSISSAVPSQC 653

Mouse   420 SGSSLSAAIHRTQPWFHGRISREESQRLIG----QQGLVDGVFLVRESQRNP 467
              .|:|:||........||.||..|....|    .....|..|.....:|.|
  Fly   654 --GSVSSAISSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKP 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grb7	NP_034476.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		18/106 (17%)
		RA_GRB7	102..186	CDD:340557	26/95 (27%)
		PH_APBB1IP	224..350	CDD:269961	43/128 (34%)
		BPS	368..413	CDD:462644	6/44 (14%)
		SH2_Grb7	428..535	CDD:198276	11/44 (25%)
pico	NP_608363.1	RA_MRL_MIG10	366..451	CDD:340555	26/84 (31%)
		PH_APBB1IP	489..614	CDD:269961	43/146 (29%)