DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSTF2 and Rbfox1

DIOPT Version :9

Sequence 1:	NP_001293135.1	Gene:	CSTF2 / 1478	HGNCID:	2484	Length:	597	Species:	Homo sapiens
Sequence 2:	NP_001246707.1	Gene:	Rbfox1 / 39198	FlyBaseID:	FBgn0052062	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	79/432 - (18%)
Similarity:	139/432 - (32%)	Gaps:	115/432 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    16 RSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGR 80
            :.:.|.|||:...:..|:.:|.:.|.::...:::: |.|. ||:||..:.:...|..|...|:|.
  Fly   460 KRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFN-ERGS-KGFGFVTFANSNDAERARERLHGT 522

Human    81 EFSGRALRVDNAASEKNKEEL---------KSLGTGAPVI------------------------- 111
            ...||.:.|:||.:....:::         |.....||.:
  Fly   523 VVEGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVAIQRGHVG 587

Human   112 ---ESPYGETISPEDAPESISKAVASLPPEQMFEL--------------MKQMKLCVQNSPQEA- 158
               .:||.....|...|..::.:.|:...:|..:|              .:|.:..||...|:.
  Fly   588 VVGATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVA 652

Human   159 ----RNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTN----------IPTLIAGNPQP-V 208
                :....|..|...|:.|.|.|.:        :..|:|..          :....|....| :
  Fly   653 AAAQQQHQQQQQQQQQAVQQQQAVQQ--------QQQHQQQQQQQQQQQHAAVAAAAAAASHPHM 709

Human   209 HGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQGGVPAPGQMP----AAVTGPGP 269
            |.|    .::...:...||..|.|::...........:|.|:...:..|...|    ||......
  Fly   710 HAA----HAHAHAHALGPQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAAAAAYAAR 770

Human   270 GSLAPGGGMQAQVGMPGSGPVSME------------RGQGTLQHSP----VGPAGP-----ASIE 313
            .|.|.|.....|.....:...||.            .|...:.:.|    ...|.|     |:..
  Fly   771 LSAATGATQSPQTAAAAAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKP 835

Human   314 RVQVPMQDPRAAMQRGSLPA---------NVPTPRGLLGDAP 346
            ..:||...|.|.:.|.::..         .:|.|:.:|..||
  Fly   836 VTEVPAAQPAAILNRRTVTTLNSNPHTINRIPVPQNVLATAP 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSTF2	NP_001293135.1	PABP-1234	4..352	CDD:130689	79/432 (18%)
		RRM_CSTF2_CSTF2T	18..92	CDD:241115	20/73 (27%)
		CSTF2_hinge	112..191	CDD:373015	17/97 (18%)
		PRK14718	<412..>469	CDD:173181
		CSTF_C	553..593	CDD:373006
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	22/83 (27%)
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:240853	21/76 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910