Protein Alignment HIPK4 and mbk-1

DIOPT Version :9

• Sequence 1: XP_006723099.1
• Gene: HIPK4 / 147746
• HGNCID: 19007
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_510460.2
• Gene: mbk-1 / 181578
• WormBaseID: WBGene00003149
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 412
• Identity: 139/412 - (33%)
• Similarity: 205/412 - (49%)
• Gaps: 41/412 - (9%)

Human    17 LGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLE--FF 79
            :|||:||:|.|.:.....|.|||||:||........:.|:.||......|.:..:.|..|:  |.
 Worm   334 VGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTLKGHFV 398

Human    80 HDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK--ELAIIHADLKPENI 142
            |.| ...||||||..||::..|..:|..:.....|....|:...|..|.  ||:|||.||||||:
 Worm   399 HRA-HLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPENV 462

Human   143 MLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAE 207
            :||:..|.  :::||||||:.......|   .||||||||:||:|||:.:..|:|:|||||::.|
 Worm   463 LLVNAKRS--QIRVIDFGSSCQTGHRIY---QYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVE 522

Human   208 LHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAE 272
            :|.|.||:.|::|.||:..|.|..|:|...:|....|.|.:|.:...    ..:..|.:.|....
 Worm   523 MHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTED----GIYYCKKTRDGYRH 583

Human   273 TKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS 337
            |...|..|:.:.:     :...:||....||..|....    .|.....:||||||.::..:|||
 Worm   584 TYKAPGARKLHEI-----LGVTSGGPGGRRLGEPGHSV----EDYSKFKDLIKRMLQFDPKQRIS 639

Human   338 PSAALRHPFVSMQQLR--SAHETTH-----YYQLSLR--SYRLSLQVEGKPPTPVVAAEDGTPYY 393
            |...:||||:..::.|  |....:|     ..||.::  |.::| ||...|....|..||...|
 Worm   640 PYYVVRHPFLKQKEERVPSQPPVSHSNLQQQQQLYIQQPSSQMS-QVMESPSVGSVYVEDNGMY- 702

Human   394 CLAEEKEAAGMGS--VAGSSPF 413
                 ::|.|..:  ::.:|.|
 Worm   703 -----RQAPGSSANPISVTSSF 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK4	XP_006723099.1	PKc_like	11..347	CDD:304357	120/333 (36%)
		S_TKc	11..347	CDD:214567	120/333 (36%)
mbk-1	NP_510460.2	PKc_DYRK1	312..651	CDD:271128	121/335 (36%)
		S_TKc	326..649	CDD:214567	120/333 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161462955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740