DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgrg1 and mthl1

DIOPT Version :9

Sequence 1:	XP_006530743.1	Gene:	Adgrg1 / 14766	MGIID:	1340051	Length:	718	Species:	Mus musculus
Sequence 2:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	76/396 - (19%)
Similarity:	139/396 - (35%)	Gaps:	102/396 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse   365 QHQPQPKNVTLQCVF------WVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLMVSS 423
            |.:.:.|.:..|.:|      .:.|  .|..|:...|..:.:.:...|..:...:.:.:..:|:.
  Fly   288 QREGEVKIIACQHLFSSAAGAGIHD--GSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAG 350

Mouse   424 TEVEATHK--HYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLSAVFLLDVSFL 486
            ..:.|.|.  |:...:.||.|                               ||....||.:..|
  Fly   351 FLLPAVHHALHWRCQICYVTC-------------------------------LLFGKILLAIEEL 384

Mouse   487 LSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLK-------- 543
            .|   :|....|||.|.|:.:.|..||...|:....:|::    ..|..:.|..|.:
  Fly   385 SS---SLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIW----WTFRDFRPSSLERNQEALRRY 442

Mouse   544 -LSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPE----RVTYPSM-CWIRD---SLVSYVTN 599
             .|:..||.|:.:..:.|.||            :.||    |..:..: ||..:   |:.:|.
  Fly   443 LYSLYAWGGPLLITFVAACVD------------QLPETTLLRPGFGQLYCWFDNRNLSIFAYF-- 493

Mouse   600 LGLFSLVFLFNLAMLATMVVQIL-------RLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSFAS 657
            .|...|:...|:|:..:...|:.       .::..|:........|.|.:|:|:.|.....|:..
  Fly   494 YGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLV 558

Mouse   658 GTFQLVILYLFSIITSFQGFLIFL------WYWS---------MRFQAQGGPSPLKNNSDSAKLP 707
            |. ...:.:...:|.:.||..||:      ..|:         :|.......:.::::|.|..||
  Fly   559 GG-PHGVWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLP 622

Mouse   708 ISSGST 713
            ..:|.|
  Fly   623 SMAGGT 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgrg1	XP_006530743.1	PLL	60..193	CDD:376013
		GAIN_A	204..251	CDD:376045
		GPS	376..419	CDD:366827	7/48 (15%)
		7tm_GPCRs	431..698	CDD:391938	58/307 (19%)
		TM helix 1	433..458	CDD:341315	3/24 (13%)
		TM helix 2	468..490	CDD:341315	6/21 (29%)
		TM helix 3	501..528	CDD:341315	7/26 (27%)
		TM helix 4	541..561	CDD:341315	5/28 (18%)
		TM helix 5	592..621	CDD:341315	6/28 (21%)
		TM helix 6	629..656	CDD:341315	6/26 (23%)
		TM helix 7	662..687	CDD:341315	6/39 (15%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	58/302 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810