DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF480 and CG31441

DIOPT Version :9

Sequence 1:	NP_653285.2	Gene:	ZNF480 / 147657	HGNCID:	23305	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	81/341 - (23%)
Similarity:	143/341 - (41%)	Gaps:	78/341 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    27 LTFRDVAIEFSQAEWKCLDPAQRALYKDVMLENYRNLVSLGISLPDLNINSMLEQRREPWSGESE 91
            ||||:          |||:     ::|..|..|.:.|....|...:|:...:.:.:::.|.
  Fly    67 LTFRN----------KCLE-----VHKSFMAANRKLLRKKAIVDEELDKPDVEKLQQDLWD---- 112

Human    92 VKIAKNSDGRECIKGVNTGSSYALGSNAEDKPIKKQLGVSFHLHLSELELFPDERVINGCNQVEN 156
                 ::|...|:...:|.     |...||..                   .:|:..:..:..:|
  Fly   113 -----HTDQEMCVAMADTA-----GLLREDHN-------------------DNEKAKDAEDATQN 148

Human   157 FINHSSSVSCLQEMSSSVKTPIFNRNDFDDSSFLPQEQKVHLREKPYECNEHSKVFRVSSSLTKH 221
            ..|        ||....|:|                |:..|.:|:.:..:..||  .||:.:.|.
  Fly   149 EKN--------QEEQVQVQT----------------EEVEHCQEQLHNMSIISK--GVSARVPKR 187

Human   222 QVIHTVEKPYKCNSCGKVFSRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFARHQRIHTREKP 286
            ...::  |.:.|:.||.||..:::|..|.:.|:|.||:.|::|...:..::...||:.:||..:|
  Fly   188 TKRNS--KSWFCDQCGGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTDNEMRRHRILHTDARP 250

Human   287 YECNECGKVFSNNSYLARHQRIHAEEKPYKCNECGKGFSHKSSLANHWRIYTGEKPYKCDECGKA 351
            |.|..|.|.:...|....|:|.|..|:|::|..|.|.|:..|:...|..::|.::.|.|:.|.:.
  Fly   251 YACRFCSKTYRGCSSKVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQRKYHCEICDQW 315

Human   352 FYRIALLVRHQ--KIH 365
            |.|.:.|..||  |:|
  Fly   316 FLRSSHLTLHQSTKLH 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF480	NP_653285.2	KRAB	27..87	CDD:214630	13/59 (22%)
		KRAB	27..66	CDD:279668	11/38 (29%)
		COG5048	<158..501	CDD:227381	59/210 (28%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-H2C2_2	217..242	CDD:290200	7/24 (29%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		zf-H2C2_2	245..270	CDD:290200	8/24 (33%)
		C2H2 Zn finger	261..281	CDD:275368	4/19 (21%)
		zf-H2C2_2	273..298	CDD:290200	9/24 (38%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	301..326	CDD:290200	9/24 (38%)
		C2H2 Zn finger	317..336	CDD:275368	6/18 (33%)
		C2H2 Zn finger	345..365	CDD:275368	8/21 (38%)
		zf-H2C2_2	358..382	CDD:290200	5/10 (50%)
		C2H2 Zn finger	373..393	CDD:275368
		zf-H2C2_2	385..410	CDD:290200
		zf-C2H2	399..421	CDD:278523
		C2H2 Zn finger	401..421	CDD:275368
		zf-H2C2_2	413..437	CDD:290200
		C2H2 Zn finger	429..449	CDD:275368
		zf-H2C2_2	442..466	CDD:290200
		C2H2 Zn finger	457..477	CDD:275368
		zf-H2C2_2	469..494	CDD:290200
		COG5048	481..>529	CDD:227381
		C2H2 Zn finger	485..505	CDD:275368
		zf-H2C2_2	497..522	CDD:290200
		C2H2 Zn finger	513..533	CDD:275368
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	8/29 (28%)
		COG5048	<174..337	CDD:227381	51/162 (31%)
		C2H2 Zn finger	197..217	CDD:275370	7/19 (37%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..290	CDD:290200	9/21 (43%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..328	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000