DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpc1 and dally

DIOPT Version :9

Sequence 1:	NP_057905.1	Gene:	Gpc1 / 14733	MGIID:	1194891	Length:	557	Species:	Mus musculus
Sequence 2:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	140/590 - (23%)
Similarity:	234/590 - (39%)	Gaps:	82/590 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 ARGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMEL 85
            |:......:..|..|:..     |...|:..:....|...||  |..||.:..|..|.:.:....
  Fly    58 AKDAVGGSTHQCDAVKSY-----FESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMF 115

Mouse    86 ESALHDSSRALQATLATQLHGIDDHFQRLLNDSERTLQEAFPGAFGDLYTQNTRAFRDLYAEL-- 148
            |..||..:.:|:..|.|.......|...|...||......|...:..:...:......||.|:
  Fly   116 EQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMN 180

Mouse   149 RLYY-------------RG---ANLHLEETLAEFWARLLERLFKQL-HPQL-----LPDDYLDCL 191
            .|.|             ||   ...:|||.:..|:.:|....:.|: |...     |.:||::||
  Fly   181 HLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCL 245

Mouse   192 GKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV---PLAPECSRAIMKLV 253
            ....:.:.||||.|::::....::...:..|:..|..|::|:.:...:   .|...|...::|:.
  Fly   246 QHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMH 310

Mouse   254 YCAHCRGVPGA-----RPCPDYCRNVLKGCLANQAD-LDAEWRNLLDSM-VLITDKFWGPSGAES 311
            ||.:|.|...:     :.|..||:||::||.|..|. ||:.|..::||: .|:|......:|..:
  Fly   311 YCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGIIN 375

Mouse   312 VIGGVHVWLAEAINALQDNKDTLTAKVIQACGNPKVNPHGSG-----PEEKRRRGKLALQEKPST 371
            ||..:..:.:|||.|...|...|..||.:.||.|.:.|:.||     |...:...|.|....|..
  Fly   376 VIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPDPGM 440

Mouse   372 GTLEKLVSEAKAQLRDIQDFWISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQI 436
            ......:.::|       :|:.::....|.|:  .....|..||:|...|.|...::..|..:|.
  Fly   441 VLFLSTIDKSK-------EFYTTIVDNFCDEQ--QHSRDDHSCWSGDRFGDYTQLLINPGTDSQR 496

Mouse   437 NNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYGGNDV----DFQDASDDGSGSGSG--GGCPD 495
            .||||..:.......:.:.:.:|..:...:..|...|.:    |.|:...:|||.|.|  |...:
  Fly   497 YNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQNDMGEGSGGGEGQIGDDEE 561

Mouse   496 DTCGRRVSKKSSSS--RTPLTHALPGLSEQEGQ-----------KTSAATCPE-PHSFFLLFLVT 546
            :..|...|...|..  .||       :.|.||.           |||.:...| ..::.||.|||
  Fly   562 EYGGAHGSGDGSGDGPHTP-------IEESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVT 619

Mouse   547 LVLAA 551
            ::.::
  Fly   620 MLFSS 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpc1	NP_057905.1	Glypican	22..538	CDD:279494	134/574 (23%)
Gpc1	NP_057905.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..531		18/68 (26%)
dally	NP_001246685.1	Glypican	51..622	CDD:279494	140/586 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810