Protein Alignment KIF18B and kif18a

DIOPT Version :10

• Sequence 1: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Sequence 2: NP_956533.1
• Gene: kif18a / 393209
• ZFINID: ZDB-GENE-040426-862
• Length: 895
• Species: Danio rerio
• Alignment Length: 953
• Identity: 362/953 - (37%)
• Similarity: 492/953 - (51%)
• Gaps: 192/953 - (20%)

Human    15 STLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTF 79
            |.::|||||||...:|.|...:.||.|||..:|||:|:|.:..|...:..|..|..|:..|||.|
Zfish     8 SHVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKF 72

Human    80 VFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVE 144
            |||.||||.::|.:||::||.:::|..|.||||:|||||||||||||||||....||:|:||..|
Zfish    73 VFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMFLTMKE 137

Human   145 LYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLL 209
            |:.|::..:::|.|.|..||.|||||||.|||...||||:|||...|||||||:.|||.|||.:|
Zfish   138 LFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSGPLAVREDGSNGVVVQGLTLHQPKSAEHIL 202

Human   210 EILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTH 274
            |.|..|||||||||||.|||||||||:|||:::|||:...|...|:||||||||||||||||:|:
Zfish   203 EALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLAGSERASATN 267

Human   275 AKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISP 339
            .||.|||||||||||||||.||:|.||:.|.:|||:|||||||||||||||||||||||||.:||
Zfish   268 TKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDSLGGNCRTVMIANVSP 332

Human   340 SSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQ 404
            |||:||||:||||||:|||||:.:|:|||.|||.||.|||.||::.:||:..|::||:.||....
Zfish   333 SSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQKLKEYEERKA 397

Human   405 PPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQV---------- 459
            ..|...|.|.:.....|.:..|           ...:.:....|::|.|.:|.|:
Zfish   398 EAPALNPISIQKRAEFEKMSES-----------LRSVFSDRLKLRKEHLDIEKQLNESRLTMRHR 451

Human   460 -----------------------ERAMEGNSSDQEQSPE---------DEDEGPAEEVPTQMPEQ 492
                                   ||.:....|.||...:         .|:||....:..:|...
Zfish   452 ESWHQQSLIFFPDNKAERATCKYERKLASLKSHQEHLQQRLMESEKCFQENEGWLHRIENEMKLL 516

Human   493 NPTHALPES-------PRLTLQPKPVVGH-------FSARELDGDRSKQLALKVLCVAQRQYSLL 543
            ......||.       .:|.||...:..|       .|.::.:...:.:|...:|...:||:..|
Zfish   517 GHDGHTPEELKKELQCHQLQLQISDLQQHMEHMSHLISVQDQENTHTHKLVNALLSTCRRQHLAL 581

Human   544 QAANLLTPDMI-TEFETLQQLVQEEKI------EPGAEALRTSGLARGAPLAQELCS-------E 594
            :|   ::.|.. :|:|.|::||..|:.      |...:....||:  |:...:.:.|       :
Zfish   582 KA---MSADGDGSEWEELERLVHRERAVVWADQEKAEDKRDDSGI--GSTHLRPILSFSHLVSHQ 641

Human   595 SIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTP------AQGSRWPMEKKRRR- 652
            |.|..|.          ..||..::||. |.|:     ..:|.|      |:|   .::|..||
Zfish   642 STPCSSE----------KHTRRTSQRLR-PTHS-----SKDCGPHHQVAEAEG---VLKKPIRRK 687

Human   653 ----PSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQ---------PSQGPSTPKGERASSP 704
                |:.|:.|.|:.          |..|       ||.|         |.|  .||:|:..:|.
Zfish   688 LSVSPAKLDGDGPVL----------SHHP-------PDLQDVLRQEGMFPLQ--FTPEGQPHTSS 733

Human   705 CHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQE 769
            ...|        .|.:.:|         .:..|| ..|||..||.|.|.:.:. :.:..:...:.
Zfish   734 IFDP--------NSTIDIG---------HIEDPT-GANATIILSPEDPGRSTL-QALRANNANKP 779

Human   770 LSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTSACKKKRV----------ASSSVSHGRSRIARLP 824
            .:||:.|       .|..::..|| |.:..|||.:.||.          :|.:::....||.|.|
Zfish   780 ANRLEIP-------SLLDLRRSKP-SYMAMTSAAQGKRKLNCSSIGKEDSSQAMAAAPKRIKRDP 836

Human   825 SSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGRALSAGN 867
            ....|    ||.:..|.:|.....:|       ||.|::|.||
Zfish   837 CEASK----PLRIRRLGVSSENEPSR-------RVVRSVSEGN 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	222/343 (65%)
		PHA03247	<606..851	CDD:223021	62/274 (23%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	222/343 (65%)
		SMC_N	<345..572	CDD:481474	56/237 (24%)