DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF18B and kif18a

DIOPT Version :9

Sequence 1:	XP_011522687.1	Gene:	KIF18B / 146909	HGNCID:	27102	Length:	873	Species:	Homo sapiens
Sequence 2:	NP_956533.1	Gene:	kif18a / 393209	ZFINID:	ZDB-GENE-040426-862	Length:	895	Species:	Danio rerio

Alignment Length:	953	Identity:	362/953 - (37%)
Similarity:	492/953 - (51%)	Gaps:	192/953 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    15 STLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTF 79
            |.::|||||||...:|.|...:.||.|||..:|||:|:|.:..|...:..|..|..|:..|||.|
Zfish     8 SHVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKF 72

Human    80 VFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVE 144
            |||.||||.::|.:||::||.:::|..|.||||:|||||||||||||||||....||:|:||..|
Zfish    73 VFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMFLTMKE 137

Human   145 LYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLL 209
            |:.|::..:::|.|.|..||.|||||||.|||...||||:|||...|||||||:.|||.|||.:|
Zfish   138 LFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSGPLAVREDGSNGVVVQGLTLHQPKSAEHIL 202

Human   210 EILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTH 274
            |.|..|||||||||||.|||||||||:|||:::|||:...|...|:||||||||||||||||:|:
Zfish   203 EALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLAGSERASATN 267

Human   275 AKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISP 339
            .||.|||||||||||||||.||:|.||:.|.:|||:|||||||||||||||||||||||||.:||
Zfish   268 TKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDSLGGNCRTVMIANVSP 332

Human   340 SSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQ 404
            |||:||||:||||||:|||||:.:|:|||.|||.||.|||.||::.:||:..|::||:.||....
Zfish   333 SSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQKLKEYEERKA 397

Human   405 PPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQV---------- 459
            ..|...|.|.:.....|.:..|           ...:.:....|::|.|.:|.|:
Zfish   398 EAPALNPISIQKRAEFEKMSES-----------LRSVFSDRLKLRKEHLDIEKQLNESRLTMRHR 451

Human   460 -----------------------ERAMEGNSSDQEQSPE---------DEDEGPAEEVPTQMPEQ 492
                                   ||.:....|.||...:         .|:||....:..:|...
Zfish   452 ESWHQQSLIFFPDNKAERATCKYERKLASLKSHQEHLQQRLMESEKCFQENEGWLHRIENEMKLL 516

Human   493 NPTHALPES-------PRLTLQPKPVVGH-------FSARELDGDRSKQLALKVLCVAQRQYSLL 543
            ......||.       .:|.||...:..|       .|.::.:...:.:|...:|...:||:..|
Zfish   517 GHDGHTPEELKKELQCHQLQLQISDLQQHMEHMSHLISVQDQENTHTHKLVNALLSTCRRQHLAL 581

Human   544 QAANLLTPDMI-TEFETLQQLVQEEKI------EPGAEALRTSGLARGAPLAQELCS-------E 594
            :|   ::.|.. :|:|.|::||..|:.      |...:....||:  |:...:.:.|       :
Zfish   582 KA---MSADGDGSEWEELERLVHRERAVVWADQEKAEDKRDDSGI--GSTHLRPILSFSHLVSHQ 641

Human   595 SIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTP------AQGSRWPMEKKRRR- 652
            |.|..|.          ..||..::||. |.|:     ..:|.|      |:|   .::|..||
Zfish   642 STPCSSE----------KHTRRTSQRLR-PTHS-----SKDCGPHHQVAEAEG---VLKKPIRRK 687

Human   653 ----PSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQ---------PSQGPSTPKGERASSP 704
                |:.|:.|.|:.          |..|       ||.|         |.|  .||:|:..:|.
Zfish   688 LSVSPAKLDGDGPVL----------SHHP-------PDLQDVLRQEGMFPLQ--FTPEGQPHTSS 733

Human   705 CHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQE 769
            ...|        .|.:.:|         .:..|| ..|||..||.|.|.:.:. :.:..:...:.
Zfish   734 IFDP--------NSTIDIG---------HIEDPT-GANATIILSPEDPGRSTL-QALRANNANKP 779

Human   770 LSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTSACKKKRV----------ASSSVSHGRSRIARLP 824
            .:||:.|       .|..::..|| |.:..|||.:.||.          :|.:::....||.|.|
Zfish   780 ANRLEIP-------SLLDLRRSKP-SYMAMTSAAQGKRKLNCSSIGKEDSSQAMAAAPKRIKRDP 836

Human   825 SSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGRALSAGN 867
            ....|    ||.:..|.:|.....:|       ||.|::|.||
Zfish   837 CEASK----PLRIRRLGVSSENEPSR-------RVVRSVSEGN 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	222/343 (65%)
KIF18B	XP_011522687.1	KISc	18..367	CDD:214526	225/348 (65%)
kif18a	NP_956533.1	KISc	9..354	CDD:214526	223/344 (65%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	222/343 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310221at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820