DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF18B and Kif18b

DIOPT Version :9

Sequence 1:	XP_011522687.1	Gene:	KIF18B / 146909	HGNCID:	27102	Length:	873	Species:	Homo sapiens
Sequence 2:	XP_008766505.1	Gene:	Kif18b / 303575	RGDID:	1310360	Length:	841	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	621/844 - (73%)
Similarity:	688/844 - (81%)	Gaps:	19/844 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     9 VMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKK 73
            |||||||.::||||||||||:||:||||||:||||||:|||:|||.|||||||||.|:..|||||
  Rat     2 VMAVEDSVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSLSGPKKK 66

Human    74 GKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIM 138
            ||||||||||||.|.||||||||||||::||||||||||||||||||||||||||||||||||||
  Rat    67 GKDLTFVFDRVFSEVATQQDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIM 131

Human   139 YLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPA 203
            ||||:||||||||.|:||.|||||||.|||||||:|||||||||.|||||||||||.||||||||
  Rat   132 YLTTMELYRRLEACQEEKQFEVLISYLEVYNEQIYDLLEPKGPLTIREDPDKGVVVPGLSFHQPA 196

Human   204 SAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSE 268
            ||:||||:|||||.:|||||||||||||||||||||||||||||||||||::|||||||||||||
  Rat   197 SAQQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLAGSE 261

Human   269 RASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVM 333
            |||||||||||||||||||||||||||||||||||||||:||||||||||||||||:||||||||
  Rat   262 RASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDSIGGNCRTVM 326

Human   334 IAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQV 398
            |||:|||||||||||||||||||||||||:|||||.|||.||||||||||||||||||||:|||.
  Rat   327 IAAVSPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISLDHHISQYATICQQLQAEVAALREKLQT 391

Human   399 YEGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAM 463
            ||.|.|...|..|..||.. .|::|.||||.|...||.|.||..|...|.||||||.::|.:..:
  Rat   392 YEAGAQALQQRSPQPPKLS-IPQNLSSSPLQPGHSSQSCAPEFHAKYDAPQEESLGTDSQGQGTV 455

Human   464 EGNSSDQEQSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQL 528
            |.|:.:|||.|:|      ::.||||||.|    ||.||..|:|.|..:...|.:.||.:.||||
  Rat   456 EENAPEQEQPPQD------KQFPTQMPEPN----LPGSPCPTVQAKQGMNQHSLQRLDAEHSKQL 510

Human   529 ALKVLCVAQRQYSLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCS 593
            ||:||.:|||||||||||||||||||:|||||||||.||.:|.|||:.|:.|||||.||||||||
  Rat   511 ALRVLRLAQRQYSLLQAANLLTPDMISEFETLQQLVLEESMEHGAESPRSPGLARGIPLAQELCS 575

Human   594 ESIPVP-----SPLC-PEPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRR 652
            ||...|     .|.| .|...|.||||||||::|||..||||||..|:||..:.|:.|.::|:|:
  Rat   576 ESSECPLSLSLRPACSQESSRYCGPVTRTMAKQLSGLTHTLGIPLAPDCTSDKTSQKPTKEKKRK 640

Human   653 PSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIK 717
            .:..|..|..||....|||||||||||||||||..|||..|.||||||||||..|.|||||||||
  Rat   641 LNLEEPGSLPAPSVEMKRQRQSFLPCLRRGSLPKIQPSSEPRTPKGERASSPSPSSRVCPATVIK 705

Human   718 SRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAP 782
            |||||||||:|||||||.|||||||.||::|||.||||||.|.|.|:|:..||:..||||:|.||
  Rat   706 SRVPLGPSALQNCSTPLTLPTRDLNTTFNVSEESPSKPSFPEPIDWEKVSPELNGTDQPFLPSAP 770

Human   783 VPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLC 846
            |.:||.||.||  |||.|:|.||:|....|||.|||.||||||||||:|..|..:|:.|||..|
  Rat   771 VFIFTTKGRKP--SLPTTTASKKRRTVRPSVSRGRSCIARLPSSTLKKPDRPFTVPDPPLSLHC 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	309/343 (90%)
KIF18B	XP_011522687.1	KISc	18..367	CDD:214526	315/348 (91%)
Kif18b	XP_008766505.1	KISc	18..360	CDD:214526	309/341 (91%)
Kif18b	XP_008766505.1	KISc_KIP3_like	18..353	CDD:276821	303/334 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83687773
Domainoid	1	1.000	623	1.000	Domainoid score	I4531
eggNOG	1	0.900	-	-		E2759_KOG0242
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15214
Inparanoid	1	1.050	1151	1.000	Inparanoid score	I4362
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37309
OrthoDB	1	1.010	-	-		D142456at32523
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		oto143316
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310