DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF18B and klp5

DIOPT Version :9

Sequence 1:	XP_011522687.1	Gene:	KIF18B / 146909	HGNCID:	27102	Length:	873	Species:	Homo sapiens
Sequence 2:	NP_595703.1	Gene:	klp5 / 2540361	PomBaseID:	SPBC2F12.13	Length:	883	Species:	Schizosaccharomyces pombe

Alignment Length:	966	Identity:	291/966 - (30%)
Similarity:	410/966 - (42%)	Gaps:	300/966 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    15 STLQVVVRVRPPTPRE---------------LDSQRRP--------VVQVVDERVLVFNPEEPD- 55
            |::.|.|||||.:..|               ..|.|.|        ||:|:|.|||||:|  ||
pombe     5 SSITVTVRVRPFSTAESANLIASSDRLSFGTSSSLRNPGSGRQIRRVVKVLDGRVLVFDP--PDE 67

Human    56 -----------------------------GGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQ 91
                                         .||               |:||.:.|||||.|.|||
pombe    68 TTATLSATNRRLSTSQQSLARLSRKSNNSAGF---------------GRDLRYAFDRVFDETATQ 117

Human    92 QDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEK 156
            |.|::.|...:||:.|.|:|.::|||||||.|||||:.|...|||::|||..||:.|::..:.||
pombe   118 QQVYERTARPLLDNILDGFNATIFAYGATGCGKTHTISGTMQDPGLIYLTLKELFERMDHLRDEK 182

Human   157 HFEVLISYQEVYNEQIHDLL-----EPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGN 216
            .|::.:||.|:|||.|.|||     ....||.:|||.|:.:.|.||:...|.|.|::::|:.:||
pombe   183 IFDLRLSYLEIYNETIRDLLVSPTPNQAKPLNLREDADRRITVPGLTSLSPESLEEIIDIIMKGN 247

Human   217 RNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLR 281
            .|||..||:|||.||||||:.|:.:.|:.|..|:.:...:|.:|:|||||||||::|..:|.||.
pombe   248 ANRTMSPTEANAASSRSHAVLQVTLIQKPRTAGINEDHTLATLSIIDLAGSERATATKLRGSRLF 312

Human   282 EGANINRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYED 346
            ||||||:|||||.|.:|||.|.. |:.||||||||||||||.|||||||||||..:||||:.||:
pombe   313 EGANINKSLLALGNCINALCDPH-RRAHVPYRDSKLTRLLKFSLGGNCRTVMIVCVSPSSVHYEE 376

Human   347 TYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLP 411
            |:||||||:|||.|:..:..|:.|:|.|:|||.....:|:.:::.|..:|
pombe   377 THNTLKYANRAKNIKTEVLRNMISVDRHVSQYVKAIVELREQISELENRL--------------- 426

Human   412 GSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQE---QS 473
                                                         ||::.:.:.|.|||:   ||
pombe   427 ---------------------------------------------AQIDLSSQSNGSDQDAVTQS 446

Human   474 PEDEDE-GPAEEV-----PTQMPEQNPT-------------------------HALPES--PRLT 505
            ...|.: ..|..:     ...:|.||.|                         ..||.|  .|:.
pombe   447 FAHESKLAEARNLLRMTFEETLPLQNDTINKVEKVKHFDDSIRVLKYWLSCYERILPNSADERVF 511

Human   506 LQPKPVVGHFSAR-ELDGDRSKQLALKVLCVAQRQYSLL------QAANLLTPDMITEFETLQQL 563
            |....:....:.| |:..|...:|..:..   ||..|.:      :.|.:....:..|.:.|:.:
pombe   512 LVRSKLESLLTRRAEIIADIDPELVYQKF---QRSVSHIINTYKQEGATMYADVLQDEVDLLKSI 573

Human   564 VQEEKIE---------PGAEALRTSGLARGAPL----AQEL---------------------CSE 594
            ::.:.::         |..|:|..|.....:.|    .|||                     .||
pombe   574 IENQVLDAQNKVDEFTPVLESLLRSSFKASSLLKEGGMQELFSILEKWLLGIGLGEKPNISVLSE 638

Human   595 SIPVPSPLCPEPPGYTGPVTRTMAR-RL----SGPLHTLGIP-----PGPNCTPAQGSRWPMEKK 649
            |..:.|         |...:||:.| |:    :.||....:|     ..|........|.|.::.
pombe   639 SYKLNS---------TSDDSRTINRDRVHSFPTQPLLNNNLPRMFFVKSPKKPVVFSKRSPKKRV 694

Human   650 RRRPSALEADSPM----APKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERAS-------- 702
            |...|...:||..    :|.:.:|.:..:|...:..           ||||..:|..
pombe   695 RFDDSMSTSDSGASAYNSPIQTSKLKNMNFFNTMHM-----------PSTPAHKRPENKNQIDVE 748

Human   703 -------SPCHSPRVCPATVIKSRVPLGPSAMQNC-STPL-------------ALPTRDLNATFD 746
                   ||....:..|..:|||  ||......|. ||.|             :||..|   |.|
pombe   749 INLTSPVSPMLEDKPEPGLLIKS--PLEKKQEVNSESTQLDQLLAEDSSTDDVSLPHLD---TID 808

Human   747 LSEEP-PSKPSFHECIGWDKIPQELSR--LDQP--FIPRAPVPLFTMKGPKPTSSL 797
            |...| |..|..:           .||  :|.|  .:....:..|....||...||
pombe   809 LDGSPVPKVPDLN-----------FSRANMDSPTFILNNEAIHNFDFSKPKTRQSL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	185/401 (46%)
KIF18B	XP_011522687.1	KISc	18..367	CDD:214526	186/406 (46%)
klp5	NP_595703.1	KISc_KIP3_like	6..390	CDD:276821	185/401 (46%)
klp5	NP_595703.1	KIP1	35..617	CDD:227392	226/662 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	344	1.000	Domainoid score	I214
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		mtm10331
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810