DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gnat2 and Galphao

DIOPT Version :9

Sequence 1:	NP_032167.1	Gene:	Gnat2 / 14686	MGIID:	95779	Length:	354	Species:	Mus musculus
Sequence 2:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	204/356 - (57%)
Similarity:	265/356 - (74%)	Gaps:	4/356 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MGSGISAEDKELARRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEE 65
            ||...|||::..|.||:.:|:.|:||..:.||.:|||||||||||||||||||||||:.|::.|:
  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Mouse    66 CLEFKSVIYGNVLQSILAIIRAMSTLGIDYAEPSCADAGRQLNNLADSTEEGTMP--PELVDVIR 128
            ..:::.|:|.|.:||::||:|||.||.|.|:........:.:.::.....: |.|  .||:..::
  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHD-TEPFSEELLAAMK 129

Mouse   129 KLWKDGGVQACFDRAAEFQLNDSASYYLNQLDRITDPNYLPNEQDVLRSRVKTTGIIETKFSVKD 193
            :||:|.|||.||.|:.|:||||||.|:|:.|||:...:|.|.|||:||:|||||||:|..||.|:
  Fly   130 RLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKN 194

Mouse   194 LNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKF 258
            |||::||||||||||||||||||.||.||||.|:|.||.||.||:..|||.|||.||:||||:|:
  Fly   195 LNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKW 259

Mouse   259 FAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYEDAGNYIKSQFLDLNMRKDVKEIYSHM 323
            |..|||:|||||||||||||:|..|:||||||.|...|.:|..||::|| :...:...||||.||
  Fly   260 FTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQF-EAKNKSTSKEIYCHM 323

Mouse   324 TCATDTQNVKFVFDAVTDIIIKENLKDCGLF 354
            ||||||.|::||||||||:||..||:.|||:
  Fly   324 TCATDTNNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnat2	NP_032167.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		12/26 (46%)
		G-alpha	34..348	CDD:206639	185/315 (59%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	185/315 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830