DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC25A10 and CG18327

DIOPT Version :9

Sequence 1:	NP_001257882.1	Gene:	SLC25A10 / 1468	HGNCID:	10980	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001260966.1	Gene:	CG18327 / 36567	FlyBaseID:	FBgn0033904	Length:	304	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	77/330 - (23%)
Similarity:	130/330 - (39%)	Gaps:	86/330 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     8 SRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLR---------MTGMALRVVRTDGILALYSG 63
            |.:..||:|:.||...|:|::::|..:|.|.|:..|         :....:.|.:.||||.|..|
  Fly     4 SDFVLGGVAAMGAGVFTNPVEVIKTRIQLQGELAARGSHAQPYKSVFQAFVTVAKNDGILGLQKG 68

Human    64 LSASLCRQMTYSLTRFAIYETVRDRVAKG----SQGPLPFHEKVLLGSVSGLAGGFVGTPADLVN 124
            |:.:||.|...:..|.:||   ...|.||    ::|.:.|.:.:..|::.|:.|.:..:|..|:.
  Fly    69 LAPALCFQFVINSFRLSIY---THAVEKGWVHNNKGEISFAKGMFWGALGGVVGSYCASPFFLIK 130

Human   125 VRMQNDV--KLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLYCRWMCHV 187
            .::|...  ::..|.:..:|...|.:.::.|:.|:..|:.|:....||..:.:..|:
  Fly   131 TQLQAQAAKQIAVGYQHQHASMSDAIRKIYRKNGVFGLWRGSLANVSRATVASAVQI-------- 187

Human   188 PVPAPGCAEDSPDELQGGVSGRFPLRRGDSEARASGLLQGPRPSWHPPHPPHRAHFCVSGTA--- 249
                             .|.|           :|..||:......||.    ...|| ||.|
  Fly   188 -----------------AVFG-----------QAKSLLKENGVVTHPT----ILSFC-SGLAAGS 219

Human   250 ------------TQKLWHQSAILTSRG---NGWAARPDTLGSSKESQAQH-LLLGPRPPWPWPPV 298
                        |.:|::|......||   .||.   |.:.:...|:..: |..|     .||..
  Fly   220 FVSLAITPLDVVTTRLYNQGVDAQGRGIYYRGWL---DCVLTILRSEGVYGLYKG-----FWPIY 276

Human   299 LRSRP 303
            |||.|
  Fly   277 LRSAP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A10	NP_001257882.1	Mito_carr	13..93	CDD:278578	29/92 (32%)
SLC25A10	NP_001257882.1	Mito_carr	95..179	CDD:278578	17/85 (20%)
CG18327	NP_001260966.1	Mito_carr	4..87	CDD:278578	25/82 (30%)
		PTZ00169	5..293	CDD:240302	76/329 (23%)
		Mito_carr	101..201	CDD:278578	23/135 (17%)
		Mito_carr	204..296	CDD:278578	24/91 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R857
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940