DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc6a9 and GlyT

DIOPT Version :9

Sequence 1:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus
Sequence 2:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	293/633 - (46%)
Similarity:	410/633 - (64%)	Gaps:	38/633 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 IGGDTRAASAHPGMASAQGPVATPSPEQNGAV------------PSEATKKDQNLTRGNWGNQIE 54
            :|..:::.||..|.....|.|..||...:|..            |......:....||.|..:.:
  Fly     1 MGQSSKSGSAGVGGVGGGGGVVCPSTAISGCASGTALIQLDATGPGAGGAGESEHERGTWTGRFD 65

Mouse    55 FVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW- 118
            |:|:.:||:||||||||||||||.||||||:.|:.|||:..|:||.||||||||:|:.|.:.|:
  Fly    66 FLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYR 130

Mouse   119 RISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGV--LDA 181
            |..|:|:|:|.||::||..:.:|||::|....:|.|:|...||||..|...|:|..|...  .|.
  Fly   131 RFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQ 195

Mouse   182 SNLTNG--------SRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLG 238
            ...|||        :..:|...|::.|....|:| .|:|||:..:||.||..|...|.::|.|..
  Fly   196 CEATNGTYYLRTCHNATSAAENNITTLALGALKR-PPAEEYFNNFVLGLSKGIEETGSIKLSLAA 259

Mouse   239 CLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILE 303
            ||.::|.:|||||.:||:||||||||||.||||||.|||||||||.||.|||::||||.|.::..
  Fly   260 CLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLAN 324

Mouse   304 AKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMA 368
            |:||||||.|||::|..|||||||::|||||.||||:||:|::..|.|||.:||.|||||:||:|
  Fly   325 AQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLA 389

Mouse   369 NHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDE 433
            :.|.|||.:|.|.|.||||:.|||.:|.||:||:|::|||.||:.|||.:||.|:||:.|||:|.
  Fly   390 HELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDR 454

Mouse   434 VGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYG 498
            ..|  :.|.|.:|.|.||:.|::.|:..|:.:|:|||.|||.|||::|:::|:...|:.|.:|||
  Fly   455 FPN--LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYG 517

Mouse   499 HRNYFQDIQMMLG-------FPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAV 556
            .:.:..|||.|:|       |    |:.|.||:::||.:.|||.|..::|:|..|.||.||.||.
  Fly   518 SQRFLNDIQGMIGKRSWFWNF----FWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPMWAD 578

Mouse   557 AIGFLMALSSVICIPLYALFQLCRTDGD-TLLQRLKNATKPSRDWGPA 603
            |:|:::.|..|:.|.|.|..::.|.... :...|:|:..:|:.:||||
  Fly   579 AVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPA 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	285/605 (47%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	275/552 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	572	1.000	Domainoid score	I226
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3948
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44351
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10344
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900