Protein Alignment Glrb and Rdl

DIOPT Version :9

• Sequence 1: XP_036018791.1
• Gene: Glrb / 14658
• MGIID: 95751
• Length: 530
• Species: Mus musculus
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 192/608 - (31%)
• Similarity: 280/608 - (46%)
• Gaps: 125/608 - (20%)

Mouse    20 ADAPRQPRLG-WAHCHLTSDSELLGLQACH---HSCQQSPEDLARVPPNSTSNILNRLLVSYDPR 80
            |..||.|.|. |    |..:..|:..:..|   |:.|.:....:.:...:.|.||:...||||.|
  Fly    13 APLPRTPLLTIW----LAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKR 73

Mouse    81 IRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRL---KLPSDFRGSDALTVDP 142
            :|||:.|.||:|.|.:::.|..|:.|..||:.::.:.||.|.||||   |.|    |.:.|:|..
  Fly    74 VRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRP----GVETLSVGS 134

Mouse   143 TMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRC 207
            ...|.:|.||.||.|||.:.||..|..|..:.:...|.:..|:||:||.|||::|..||||.|.|
  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199

Mouse   208 KMQLESFGYTTDDLRFIWQSG-DPVQL-EKIALPQFDIKKEDIEYGN---CTKYYKGTGYYTCVE 267
            .:::||||||..|:|:.|:.| ..|.: .::.||||.:      .|:   .|:....||.|:.:.
  Fly   200 HIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV------LGHRQRATEINLTTGNYSRLA 258

Mouse   268 VIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPK 332
            ......|.:|:|::.:|.|:.|||::||:|||:|.:|:.|||.||:.:||::.:..::..|.|||
  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323

Mouse   333 VSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARI--------AKAEQADGKGGN 389
            :||||::||:|..|.:..||||:|||.|..|   .||::..|.|.        .|.:|.||....
  Fly   324 ISYVKSIDVYLGTCFVMVFASLLEYATVGYM---AKRIQMRKQRFMAIQKIAEQKKQQLDGANQQ 385

Mouse   390 AAKKNTVNGTGTPVHISTLQELPMVCQQITYQLDGWPTDTLTTQV-------------------G 435
            .|..|.....|.|..:......|           |.|...:...|                   |
  Fly   386 QANPNPNANVGGPGGVGVGPGGP-----------GGPGGGVNVGVGMGMGPEHGHGHGHHAHSHG 439

Mouse   436 ETRCKKVCTSK-----SDLRSN----DFSIVGSLPRDFELSNYD----CYGKPIE--VNNGLGKP 485
            .....|...|.     |:::.|    ..||||.|.::.....:|    ..|..:|  ||.|.|.|
  Fly   440 HPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGP 504

Mouse   486 QAKNKKP------------------PPAKPVIPTAA-------------------------KRID 507
            |:....|                  ||.....|.||                         ..||
  Fly   505 QSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDID 569

Mouse   508 LYARALFPFCFLFFNVIYWSIYL 530
            .|:|.:||.||:.||::||.|||
  Fly   570 KYSRIVFPVCFVCFNLMYWIIYL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glrb	XP_036018791.1	LIC	64..529	CDD:273305	178/557 (32%)
		LGIC_ECD_GlyR_beta	89..275	CDD:349811	70/193 (36%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	69/192 (36%)
		Neur_chan_memb	274..588	CDD:397193	91/327 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2310
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860