DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSPG4 and kon

DIOPT Version :9

Sequence 1:	NP_001888.2	Gene:	CSPG4 / 1464	HGNCID:	2466	Length:	2322	Species:	Homo sapiens
Sequence 2:	NP_001260539.1	Gene:	kon / 35104	FlyBaseID:	FBgn0032683	Length:	2381	Species:	Drosophila melanogaster

Alignment Length:	2560	Identity:	615/2560 - (24%)
Similarity:	1054/2560 - (41%)	Gaps:	443/2560 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    14 LALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQL 78
            ||....|.:....|...|.||:.::.:|:..|....:::::|.|.|..|.|.||||..|:.||:|
  Fly    14 LAWLAILQLQTVAAMKVSLFGDGYVSMPLQEAKMSTNIRVKFRTRQENAFLFLAAGRTDYCLLRL 78

Human    79 YSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPG--APLE 141
            .||.:.....:.::.::|::|.:..|:|...|.|.:...|...||.|||:: ....:||  |.|.
  Fly    79 ESGLISFSYKIERDVVQLRSPKKQKLNDLEWHDVAVQRFENNITLQVDGYI-MRKQLPGDLAALN 142

Human   142 VPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSLLR--------PLTPDVHEGCAEEFSA 198
            :.:|.|:||.|.....:|.... ..|||:.....|..::::        ..:..|...|:.||..
  Fly   143 IHFGTFLGGVGDFTAEFLDDVI-GFRGCISDVFYNNINIIKRAKDRTSHTTSTGVAWTCSTEFEG 206

Human   199 S--DDVALGFSGPHSLAAFPAWGTQDEGTLEF-TLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHL 260
            |  |.::...:..:||....::...:..:|:| |:.:    |.:.|..||.  |||.::|.:.||
  Fly   207 SIQDSISFMRNDSYSLMMKESYAMGETLSLQFRTMAS----AGVIFFNGGY--DFILLEIEDQHL 265

Human   261 RAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYP-----THTSNRGVLSYLEPRG 320
            :....|....|....:..::||:.|.|.:..||...|:|:|...     ||.:.......||.
  Fly   266 KVTFNKAGSLVQFMTNEHISDGKWHRVFLRYNAAIAELSLDDATSGYRGTHANETKASINLEK-- 328

Human   321 SLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGC--RLE 383
            |:..||:..|..|.|....|.:    ...|..|||.|:.||....|..|..::|::|..|  :..
  Fly   329 SVFFGGVQEEMRRRLISKGLRI----NEISFKGCMRDILVNDLPLGFAEMTISRSLALNCLWKYP 389

Human   384 EEEYE--------------------DDAY-------GHYEAFSTLAPEAWPAMELPEPCVPEPGL 421
            ..||.                    |.:|       |.::.|:..:||
  Fly   390 CVEYNPCLKSGICSQHGVDGFICYCDQSYCIKADFQGPFKIFTETSPE----------------- 437

Human   422 PPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLME-AELRKSQVLFSVTRGARHGELELDI 485
                   .:||.:||:.:.|||||:|....:...|||.. ..|.:..::|.|....::|:| |..
  Fly   438 -------LELLYVSPMQLLEGGTAFLSPHFIDIILDLRRYPSLNEQSIIFHVVHQPKYGQL-LQY 494

Human   486 PGAQA----RKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARV-PMPSCLRRGQTYLLPIQ 545
            ...:|    .:.|.|:|:...|.:::|:|.|:.:|...|::.:...| .:|..:.....:||...
  Fly   495 SAEKAIFVPCRTFNLVDLATDKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHAN 559

Human   546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRD--- 607
            :.|:||||.:......::.::|..::.|..::|...||||....|.:.:|.|.|  |.|...
  Fly   560 ITPINDPPQLRLHSHKILRVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQS--PQETFGCFI 622

Human   608 QPGEPATEFSCRELEAGSLVYVHRGGPAQ----DLTFRVSDGLQASPPATLKVVAIRP-AIQIHR 667
            ..|...:.||..|:..|.:.|::....|:    :|..:||||::.|....|. |::.| .:::..
  Fly   623 VGGATTSAFSQAEVNVGKVSYLYNSTTAESFSYELQLQVSDGIETSETVYLP-VSVHPLELRLVN 686

Human   668 STGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ--KQGAGGVEGAEWWATQA 730
            :|||.:...|::||..||||:.||||...:.:.:.:..|.|.|.||  :|..|.....:|
  Fly   687 NTGLIMIHKSSLPISTANLSIGTNAVDDHIDIRYDIVKAPQHGVLQRLRQIDGSWVNVDW----- 746

Human   731 FHQRDVEQGRVRYL-STD-PQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLH 793
            |....:..|.:||| |:| |....:..:.:.      |........|.:|..|..:...|...:.
  Fly   747 FSDSQLLLGHIRYLHSSDFPWQDEFKFIASF------GFVTTQTFDFRITFTRLRITSTRPSQIS 805

Human   794 TQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQ--GFTQDDIQAGR 856
            ...:::..||:..|.......|....:..|::.:..|.|.:.::|:|.:..:  .|||.||:..|
  Fly   806 INGSREILLTSDVLSYETTPIGSFARSVIYKITKPTRYGGIYVEGSRKAAKKLDSFTQQDIEKRR 870

Human   857 VTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLTNVL-------LVVPEGGE 914
            :.|.....:..:..|...|.|:............|:. ..||.  |.|.|       |.|.||..
  Fly   871 IRYQTHHTSYSSFSDHLEFVVSVAECDDVAGVLEINY-RPPDE--LINKLGYQNHEPLQVQEGER 932

Human   915 GVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQ-DKTTMVTSFTNEDLLRGRLVYQHDDSE 978
            .:::.:|..::.....|..::|...|.||.:.....| ..||.|..||.|.|.|..:.|.|||:|
  Fly   933 ALITKNHFGIRFNIYESLQFQVSLSPEHGVICKYDEQTGLTTPVEMFTLEQLFRNDIYYCHDDTE 997

Human   979 TTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQT-ISRIFHVARGGRRLLTTDDV 1042
            :|.|....:..     |||....:......|.|:.|||:.|.:| |.|:|||.|.|.|.|....:
  Fly   998 STRDTFELLIL-----SGDETDLQFVSNMEVHIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVL 1057

Human  1043 AFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR-------FTQEDLRKRRVLFVHSGADR 1100
            .:.|||       :.....|:.:   :.|.......|:       |||:|:..||::|.|:|||.
  Fly  1058 QYLDAD-------VNTNHTDIHY---IHVSSTNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADS 1112

Human  1101 GWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVH 1165
            |.....|:|.:|:...|||::||:|::.:...::.:|.:|....:......|:||||::. ||::
  Fly  1113 GTASFIVTDREHEVNGLLEIRASDPFVSMMATNASIVQEGKFVVLKNKDFILETNLDMKL-DEIY 1176

Human  1166 YHVTAGPRWGQLV---RA--GQPATA------------FSQQDLLDGAVLYSHNGSLSPRDTMAF 1213
            |.|...|.:|.|:   ||  |:..|.            |:..|:....::| .|..::..|.:.:
  Fly  1177 YEVIKPPSYGILMYLSRANEGENGTTIYKATNYTSLSNFTHLDIERERLVY-WNTEIASMDKVRY 1240

Human  1214 SVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSV 1278
            .|....:..:..:...|.......||::.::..:||.:..:..|.||.||.....:.|.||.|.|
  Fly  1241 RVHIKNITAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVLISRDVLEVVHPNISPGDITFLV 1305

Human  1279 KSPPSAGYLVMVSRGALADEPPSLDP---VQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGL 1340
            .|.|..|||.|.|.        |.|.   .:.|.|.:|:|.::.|:.:.....:|.|..||.:|:
  Fly  1306 TSSPMHGYLEMQSM--------SFDDEYNCKVFDQSSVNTEKMFYIQAGVNQSTDYFVFDVTNGI 1362

Human  1341 GAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ--VLEPPQH 1403
             ..|..:::::.::|..:.:.:...||.||.::.|.|..::   ||.....|..|:  |...|..
  Fly  1363 -TWLRQLMIKIVIIPEKLYMHSNIISVVEGKTVQLNPTDIQ---PYSEYYRGKILEYIVTITPSS 1423

Human  1404 GALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVLMANASEMDRQSHPVAFTVTVLP 1468
            |.:...:....|    |:.:.:|:..|:|||:|||..|||..|:|.|  .:::|.|......|:.
  Fly  1424 GHVLAGNSKVKR----FTQKQLEQGSIQYVHNGSENATDSITLVAMA--RNKESVPFELEFAVVQ 1482

Human  1469 VNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRS 1533
            |||:.|::.||||||:|.|....|....|.:.|.|:..|:|.:.:.....|.:..:.||..::..
  Fly  1483 VNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSAPHQKIEH 1547

Human  1534 FTQAQLDGGLVLFSHRGTLDGGFR-----FRLSDGEHTSPGHFFRVTAQ------KQVLLSLKGS 1587
            |||||::...:.|.|    |...|     |.::||       .|..|.|      |.:.:..:.:
  Fly  1548 FTQAQINLEEIYFMH----DSNSRRNELSFVVTDG-------LFNTTTQMLNIEIKPIEILAEHN 1601

Human  1588 QTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDS--TGEALVNFTQAE 1650
            :.|.|.|.:.:.:....|....|  .:.:.:.|.:...|.|||:.:...|:  |.| :..|||.:
  Fly  1602 ENLHVFPLTKKQILRDYLHFKCS--DEEREIRYNITVPPSLGRIVNEFIDNGFTKE-VSEFTQND 1663

Human  1651 VYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAA-----------TLAVAVSFEAACPQRP 1704
            |..|:|.|||...         .:|.:.:.....||.|           .:.::||........|
  Fly  1664 VDNGHIFYEHTAV---------IMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLLRFLP 1719

Human  1705 SHLWKNKGLWVPEGQRARITVAALDASNLL------ASVPSPQRSEHDVLFQVTQFPSRGQLLVS 1763
                .|| |.|.||....|   .||.|.:|      |.:.:|     ::..:..|.|:.|.:.:.
  Fly  1720 ----VNK-LNVDEGGSVPI---KLDFSKILEYLKTKAGINNP-----ELFIEAIQKPTHGNIGLG 1771

Human  1764 EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQD----------GFHFRAHLQGPAGASVAGPQTS 1818
            .|..|..:.|  .|.....::.|.|....|.:|          |..|..:|..|
  Fly  1772 HEFKHMQRYH--PSDFFTKKVYYIHDHSDTLEDTILMSVYLTQGNIFLCNLTIP----------- 1823

Human  1819 EAFAITVRDVNERPPQPQASVP-LRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLS 1882
                :::..:|::|......:| :.:..|....|:|..|...|.|:.|.||.|:|...|..|.|.
  Fly  1824 ----VSINPINDQPFHLVTHLPQMTVVEGENRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVLR 1884

Human  1883 LVGGGLGP------VTRFTQADVDSGRLAFVANGSSVAGIFQLSMSDGASPPL--PMSLAVD--- 1936
            .:.....|      ..:|||||:::.|:.:|..|...:..|..::|||.|.|.  ..::.:|
  Fly  1885 KITNDGRPEDLLAFSNQFTQADINNDRIIYVHFGMPQSTTFCFTVSDGQSNPAYEIFTIKIDSIH 1949

Human  1937 ILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQGPQYGHLLVGGRPTSAFS 2001
            :.|||    ::||::|.|....:.:....:.|.::......:|.:...|.:|.::...:||..|:
  Fly  1950 LQPSA----MQAPVKVQQGATTAPMRLDHIGVSTNVHMERLSYNVTNSPLFGIIVYKHQPTLRFT 2010

Human  2002 QFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVNVTVRA-----LLHVWAGGPWPQGATL 2061
            |.|::..::.:..|:.:.|:|.|:|.|...|.|..|.|:|.:..     :..:........|..:
  Fly  2011 QQQLETSQISYMQTDLNRSNDSFQVSAYVPGTNYVAQVDVVMEVEPVIQINDIVMKEAESSGGKI 2075

Human  2062 RLDPTVLDAGELANRTGSV-PRFRLLEGPRHGRVVRVPRA---RTEPGGSQLVEQFTQQDLEDGR 2122
            :|..::.:...|:.:.... |:|.:...|..|::.::.|:   .|:....:....|:.::|..|.
  Fly  2076 KLITSLDNDNPLSLKLNKFNPKFVITRMPSTGQIRKIIRSTGLTTDGQSDRSTNIFSYKELRSGV 2140

Human  2123 LGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDFATEPYNAARPYSVALLSVPEAARTEAG 2187
            :.. |............||...:|..:.|.||.|:                  :|:...:|.|
  Fly  2141 VYF-VPHESVEETEADHDSFDYQLLIKTVQPAQAT------------------VSIEYRSRVE-- 2184

Human  2188 KPESSTPTGEPGPMASSPEPAVAKGGFLSFLEANMFSVIIPMCLVLLLLALILPLLFYLRKRNKT 2252
                .|.|...|          :.|..:::|.......|:.:||:::||.|         |..|.
  Fly  2185 ----ETETVHLG----------SAGLSINYLAIGCAIFIVLICLLIVLLIL---------KIRKL 2226

Human  2253 GKHDVQV-------------LT----------------------AKPRNGLAGDTETFRKVEPGQ 2282
            .||...:             ||                      :.|..|.:.....|..:...:
  Fly  2227 RKHKADISKDQPPALPCPPDLTSVSPQHHLHHHHGHHYASSEADSVPATGNSTPLPGFSNIPHCK 2291

Human  2283 AIPLTAVPGQGP-------PPGGQPDPELLQ---------------------------FCRTP-- 2311
            .||:.:...:.|       ....|.||:.:.                           :...|
  Fly  2292 IIPVESYKHEYPDYDPDEEETDDQCDPQQMMLPQRYNPYHMEHDAWSSSCDMANDFAGYASVPQS 2356

Human  2312 --------------NPALKNGQYWV 2322
                          ||.|:..||||
  Fly  2357 ISGSVSSPPSAPPTNPLLRRNQYWV 2381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSPG4	NP_001888.2	LamG	29..176	CDD:238058	45/148 (30%)
		Globular or compact configuration stabilized by disulfide bonds	30..639		167/668 (25%)
		Neurite growth inhibition. /evidence=ECO:0000250	30..639		167/668 (25%)
		LamG	203..361	CDD:238058	42/163 (26%)
		Cadherin_3	494..645	CDD:292802	41/158 (26%)
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201, ECO:0000269\|PubMed:12220645	553..645		24/98 (24%)
		Interaction with COL6A2. /evidence=ECO:0000250	574..1040		132/488 (27%)
		Cadherin_3	616..743	CDD:292802	39/133 (29%)
		Interaction with COL5A1. /evidence=ECO:0000250	631..1446		228/863 (26%)
		Cadherin_3	731..878	CDD:292802	31/150 (21%)
		Cadherin_3	847..989	CDD:292802	42/149 (28%)
		Cadherin_3	960..1110	CDD:292802	50/157 (32%)
		Cadherin_3	1187..1336	CDD:292802	37/151 (25%)
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201, ECO:0000269\|PubMed:12220645	1356..1449		27/94 (29%)
		Cadherin_3	1420..1563	CDD:292802	49/147 (33%)
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201, ECO:0000269\|PubMed:12220645	1473..1563		28/94 (30%)
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201, ECO:0000269\|PubMed:12220645	1581..1679		23/99 (23%)
		Neurite growth inhibition. /evidence=ECO:0000250	1586..2221		145/684 (21%)
		Cysteine-containing	1587..2221		145/683 (21%)
		Cadherin_3	1646..1802	CDD:292802	42/182 (23%)
		Cadherin_3	1774..1924	CDD:292802	37/166 (22%)
		Cadherin_3	2000..2123	CDD:292802	26/131 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2182..2206		5/23 (22%)
		PDZ-binding	2320..2322		1/1 (100%)
kon	NP_001260539.1	LamG	30..176	CDD:238058	45/147 (31%)
		LamG	211..365	CDD:238058	42/165 (25%)
		Cadherin_3	507..664	CDD:292802	41/158 (26%)
		Cadherin_3	631..776	CDD:292802	45/150 (30%)
		Cadherin_3	747..892	CDD:292802	31/150 (21%)
		Cadherin_3	861..1005	CDD:292802	42/146 (29%)
		Cadherin_3	979..1121	CDD:292802	50/156 (32%)
		Cadherin_3	1093..1242	CDD:292802	44/150 (29%)
		Cadherin_3	<1264..1361	CDD:292802	32/104 (31%)
		Cadherin_3	1330..1464	CDD:292802	39/141 (28%)
		Cadherin_3	1436..1578	CDD:292802	49/147 (33%)
		Cadherin_3	1789..1932	CDD:292802	36/157 (23%)
		Cadherin_3	2009..2163	CDD:292802	29/154 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159688
Domainoid	1	1.000	61	1.000	Domainoid score	I10515
eggNOG	1	0.900	-	-		E1_KOG3597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46545
OrthoDB	1	1.010	-	-		D119072at33208
OrthoFinder	1	1.000	-	-		FOG0003479
OrthoInspector	1	1.000	-	-		oto91048
orthoMCL	1	0.900	-	-		OOG6_106870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4086
SonicParanoid	1	1.000	-	-		X2369
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700