DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NCAN and ncan

DIOPT Version :10

Sequence 1:NP_004377.2 Gene:NCAN / 1463 HGNCID:2465 Length:1321 Species:Homo sapiens
Sequence 2:XP_002936378.2 Gene:ncan / 779471 XenbaseID:XB-GENE-961217 Length:1608 Species:Xenopus tropicalis


Alignment Length:1671 Identity:587/1671 - (35%)
Similarity:784/1671 - (46%) Gaps:455/1671 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    11 LLMLQMLLFVAG-----EQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQP----- 65
            |:...:.||:.|     ..|::|    :.:.||:.:.....|:.:||:.|||||||.|.|     
 Frog     9 LITFGVWLFLTGTVCIDTTGSED----AAKTLHIHRHQRDMVRCSLAQSVALPCLFLLHPSHPPQ 69

Human    66 RPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPL 130
            :|:...::|||||::::...||: ::|:|||:||||:||:.::||||||.||..|.||||:|...
 Frog    70 QPNDTSESPRIKWSRLQPGIGQK-EVPVLVARDNVVKVARGYEGRVSLPGYPHNRYNATLVLSSA 133

Human   131 RASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHL 195
            |.||||:|||:|:.||:||||.|||||||:|||||:|.:||||||.||..:|:.:|.:||:|..|
 Frog   134 RVSDSGVYRCEVIYGIDDEQDTVPLEVTGLVFHYRAASNRYALTFPEAVRSCQENSGVIASPEQL 198

Human   196 QAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGG 260
            |||||||.||||||||||.:|||||...||||||||::|||||:||.|:.||.|||||:.....|
 Frog   199 QAAFEDGLDNCDAGWLSDHSVRYPIKTPRPGCYGDRNNLPGVRTYGERDLQETYDVYCYTEGPQG 263

Human   261 EVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRC 325
            :|:||  ..:.||..|...|.|.|..||.||||:.||.:|:||||||||||.||||||:.|||.|
 Frog   264 DVYYV--PEKSTLLEASNSCLRDGGMLAKVGQLYSAWRKGMDQCDPGWLADNSVRYPIRNPRRNC 326

Human   326 GGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTS-------QHG--------------DLE 369
            ||..|||||:|::.||||||:|..:|.||||.|...|:       |.|              :|:
 Frog   327 GGEEPGVRTLYQYPNRTGFPNPTRKFGAYCFEALQATAPTLLGNKQQGPAFMLQEDRRLINPELQ 391

Human   370 TPSSGDEGE--------------------ILSAEG-------------------PPVRELEPTLE 395
            :..||...|                    ....||                   ||.:.|:|:.:
 Frog   392 SQESGQTKESEFNNVLPSTDSLISTTTHGFFQMEGSYPRILGSSKEIAKEINVLPPKQFLQPSSK 456

Human   396 EEEVVTPDFQEPLVSS-------------GEEETLILEEK-QESQQTLSPTPGDPM-------LA 439
            ||::.|.. :||:...             |.:||   |.| ||:.:|.|.:  ||:       .|
 Frog   457 EEQLQTVT-REPMEGDRLLSLRPEALTFWGTQET---ETKTQETGETKSFS--DPLRDKSRQPSA 515

Human   440 SWPTGEVWLSTVAPSPSDMGAGTAASSHT-----EVAPTDPMPRRRGRFKGLNGRYFQQ---QEP 496
            |....|.|...|      :.....:..||     |    .|:...:....|::....:|   .||
 Frog   516 SRVREEDWSLNV------VDRELKSREHTWRDFLE----QPVADSKEELPGIDYSVDEQALVNEP 570

Human   497 EP---------------GLQGGM--------EA--SAQPPTSEAAV------------------- 517
            .|               |.:..:        ||  ||.|.|||.::                   
 Frog   571 RPFPEDDRNSLHLTWNLGDKDSLFKETDTFNEAATSAIPETSEPSIYLSKMSLQNNITSHQSSLF 635

Human   518 ------------------NQ-----MEPPLAMAVTEMLGSGQSRSPW-------ADLTNEVDMPG 552
                              ||     .|....|...|..|..|..|.:       .|||.|.....
 Frog   636 KEPDQSSKIRLPGDTGSSNQNIRGLQEKEENMNYKEEKGDTQIHSVYDKMQKNNVDLTTEAFQRS 700

Human   553 A--------------GSAGGKS--------------------------SPEPW---------LWP 568
            |              |:.|.|:                          :.||.         .:|
 Frog   701 ALHTSESQSVFNEADGTTGKKTRLNEQREDKEMNSRTLFATHSDANDDNNEPGQQEFTVIYSKYP 765

Human   569 PTMVPPSISGH--------------SRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPW 619
            ||.:.|..:|.              |...|.:|.:|      ...|.:..:..::|.|:.....|
 Frog   766 PTTMDPMGNGQLEIYYRAMLGENHMSSVDVQDLPQA------VTVPGVDGNSFQSTTSSRLKNTW 824

Human   620 EAFPVATSPD-------------------LPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATA 665
            .      :|:                   ...|.:....|..:||....|.:.:...:...|.:.
 Frog   825 R------NPENMSKNSFVDEKAQNGGYGGTEKMIVNNTSKTEILPTTENIESFSGDSKEKDENSL 883

Human   666 --TAPPSPAAETKV---YSLPLSLTPT--------------GQGGEAMPTTPESP---------- 701
              .:.|.|:..|::   :..|....|.              .:.||..|:..|..          
 Frog   884 LNQSLPKPSVVTQISDDFYFPTVDHPNIEAKSIIRDRAIKPHENGEQYPSFQERQGKERTFSAKL 948

Human   702 RADFR------ETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGV 760
            .:.|:      ||.|....::|.::.|.:.   |..|....|.:.|   ..|......|..|.  
 Frog   949 ASTFKKIMAQLETKEVISKELNVSDASITD---SAFRKQEPGMLNT---VHPPDNDSYPPEEK-- 1005

Human   761 FDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAP------LGSPGVFLVPKVTPNLEPWVA 819
            ..|||..|..| ..::.:|:.....:......|.||.|      :.|..:..:...|..:|..:|
 Frog  1006 VKTAEMTTQYL-INMNSIQNTESEGWRIDKALSKPSFPFTTDMTMNSDNLQKLTPTTERVELIMA 1069

Human   820 T---------------------------DEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEE---- 853
            |                           |.|...:...:...|..:..|.......:..:|    
 Frog  1070 TVNPRNEKAVAYNLLDHQTSVSALQLSPDRGQNNSEFTNQTKPISTQDSNNTVAADEYIQELVDK 1134

Human   854 -------AESTTLSPQVALDT--SIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQG 909
                   ||:|....|...|:  .::|....||: |..|.|...|:..|::.|       :|:.|
 Frog  1135 THSLSTAAENTIKLAQTTSDSFPRVITERNNLEE-DAFGTPISPTIVWSNTTP-------LESAG 1191

Human   910 TSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFE-LEV 973
            .|..     .::...|...|...|:.........||       ..||..        ||:. |:.
 Frog  1192 WSSI-----LNNKYSKQTSPTAVPSVDETDHHGHVS-------LSPSQK--------EDYSTLDS 1236

Human   974 LAG------SPGVE--SFWE-EVASG--EEPAL---------PGTPMNAGAEEVHSDPCENNPCL 1018
            |.|      :|.:|  ||.| ::.||  |:.:|         .|.|          .||.:||||
 Frog  1237 LLGYLGNTEAPEIEEASFHEKDLGSGLDEDSSLWMIEDHTSTQGEP----------QPCSHNPCL 1291

Human  1019 HGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEK 1083
            |.|||.:||:.|.|.|.:|::|||||||||:||.:||:||||||||:|.|:||||.|||||.|.|
 Frog  1292 HMGTCQSNGSTYSCICHKGYSGENCEIDIDECLSNPCQNGGTCIDEINSFLCLCLSSYGGSTCGK 1356

Human  1084 DTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLN 1148
            ||||||..||||||.||:||..||.||:||:|||||:|||||:|||||.:|||||||||||||||
 Frog  1357 DTEGCDHNWHKFQGSCYQYFPKRRPWEEAERDCRRRAGHLTSIHSPEEQTFINSFGHENTWIGLN 1421

Human  1149 DRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTV 1213
            ||.||:||||||||.||:|||:..||||||:|||||||||:||.|:||||||||||||:||||||
 Frog  1422 DRTVEQDFQWTDNTALQYENWKNQQPDNFFSGGEDCVVMVSHEEGKWNDVPCNYNLPYICKKGTV 1486

Human  1214 LCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSH 1278
            ||..||.|:||.|||.|:.||::|:||||||.:||.|.|:.||||..||:||||:|.|.||||.|
 Frog  1487 LCNSPPEVKNAHLIGKRREKYSIHSTVRYQCQDGFIQRHIPTIRCHRNGRWDRPRIQCVKPRRHH 1551

Human  1279 RMRRHHH----------------HHQHHHQHHHHKSRKERRKHKKH 1308
            |.|||||                ||.:||.||.|||.:||||..:|
 Frog  1552 RARRHHHQHGHHLHKQHHHHKHNHHHNHHHHHQHKSHRERRKEDRH 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCANNP_004377.2 Ig_Neurocan 41..162 CDD:409483 66/125 (53%)
Ig strand A 41..44 CDD:409483 0/2 (0%)
Ig strand A' 47..49 CDD:409483 1/1 (100%)
Ig strand B 53..61 CDD:409483 5/7 (71%)
Ig strand C 75..81 CDD:409483 4/5 (80%)
Ig strand C' 90..93 CDD:409483 0/2 (0%)
Ig strand D 111..116 CDD:409483 4/4 (100%)
Ig strand E 122..128 CDD:409483 4/5 (80%)
Ig strand F 136..143 CDD:409483 4/6 (67%)
Ig strand G 153..162 CDD:409483 7/8 (88%)
Link_domain_CSPGs_modules_1_3 160..254 CDD:239594 64/93 (69%)
Link_domain_CSPGs_modules_2_4 261..356 CDD:239597 56/94 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..414 19/124 (15%)
PHA03247 <421..964 CDD:223021 134/795 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..479 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 9/43 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..579 17/102 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..731 12/78 (15%)
O-glycosylated at one site 708..712 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 820..844 5/50 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 876..955 16/78 (21%)
EGF 1012..1042 CDD:394967 16/29 (55%)
EGF_CA 1046..1082 CDD:238011 26/35 (74%)
CLECT 1088..1211 CDD:470576 97/122 (80%)
CCP 1215..1271 CDD:153056 34/55 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1321 23/50 (46%)
ncanXP_002936378.2 Ig_Neurocan 40..165 CDD:409483 66/125 (53%)
Ig strand A 40..43 CDD:409483 0/2 (0%)
Ig strand A' 46..48 CDD:409483 1/1 (100%)
Ig strand B 52..60 CDD:409483 5/7 (71%)
Ig strand C 79..85 CDD:409483 4/5 (80%)
Ig strand C' 93..96 CDD:409483 0/2 (0%)
Ig strand D 114..119 CDD:409483 4/4 (100%)
Ig strand E 125..131 CDD:409483 4/5 (80%)
Ig strand F 139..146 CDD:409483 4/6 (67%)
Ig strand G 156..165 CDD:409483 7/8 (88%)
Link_domain_CSPGs_modules_1_3 164..257 CDD:239594 64/92 (70%)
Link_domain_CSPGs_modules_2_4 264..357 CDD:239597 56/94 (60%)
EGF 1285..1315 CDD:394967 16/29 (55%)
EGF_CA 1319..1354 CDD:238011 26/34 (76%)
CLECT 1361..1484 CDD:470576 97/122 (80%)
CCP 1488..1545 CDD:153056 34/56 (61%)

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