Protein Alignment NCAN and clec-49

DIOPT Version :10

• Sequence 1: NP_004377.2
• Gene: NCAN / 1463
• HGNCID: 2465
• Length: 1321
• Species: Homo sapiens
• Sequence 2: NP_507829.1
• Gene: clec-49 / 180298
• WormBaseID: WBGene00012251
• Length: 321
• Species: Caenorhabditis elegans
• Alignment Length: 298
• Identity: 81/298 - (27%)
• Similarity: 117/298 - (39%)
• Gaps: 87/298 - (29%)

Human   938 VGESASVSSGEPTVPW-DPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPAL----PG 997
            :|.:...:||  |..| |||     ||....:::|    |.|         .||.:.|:    .|
 Worm    87 IGATDLETSG--TWKWTDPS-----VTFDYSNWQL----GEP---------QSGSDCAIQDKGDG 131

Human   998 TPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCI 1062
            |....|........|. .|.:...||....|....:|...               :||.
 Worm   132 TWSAIGCTSYRPYVCV-TPVIMTATCPPITTPIPTTCPTP---------------APCP------ 174

Human  1063 DEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQ--GHCYRYFAHRRAWEDAEKDCRRRSGHLTS 1125
                  :..|:||            ||:||..|.  ..|||.: |...:.|||..|....|||.|
 Worm   175 ------IKQCVPS------------CDQGWTYFSPTDFCYRVY-HGEKFNDAEASCVLLGGHLAS 220

Human  1126 VHSPEEHSFINSFG--------HEN-TWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGG 1181
            :||..|::|:|:..        :|: .|||:  |.|.:|:.|||.|...:.||...||||  ...
 Worm   221 IHSLTENTFVNNIASCGIKEGKYEHLAWIGM--RKVGQDWVWTDGTPSDYFNWAPKQPDN--PKK 281

Human  1182 EDCVVM---VAHES--GRWNDVPCNYNL-PYVCKKGTV 1213
            |.||..   ::|:.  ..||::.||..: .|:|||.::
 Worm   282 ELCVQTAPDLSHDKWYENWNNLECNEVMRAYICKKASI 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCAN	NP_004377.2	Ig_Neurocan	41..162	CDD:409483
		Ig strand A	41..44	CDD:409483
		Ig strand A'	47..49	CDD:409483
		Ig strand B	53..61	CDD:409483
		Ig strand C	75..81	CDD:409483
		Ig strand C'	90..93	CDD:409483
		Ig strand D	111..116	CDD:409483
		Ig strand E	122..128	CDD:409483
		Ig strand F	136..143	CDD:409483
		Ig strand G	153..162	CDD:409483
		Link_domain_CSPGs_modules_1_3	160..254	CDD:239594
		Link_domain_CSPGs_modules_2_4	261..356	CDD:239597
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..414
		PHA03247	<421..964	CDD:223021	9/26 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..479
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..513
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..579
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..731
		O-glycosylated at one site	708..712
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	820..844
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..955		5/17 (29%)
		EGF	1012..1042	CDD:394967	6/29 (21%)
		EGF_CA	1046..1082	CDD:238011	5/35 (14%)
		CLECT	1088..1211	CDD:470576	50/139 (36%)
		CCP	1215..1271	CDD:153056
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1321
clec-49	NP_507829.1	CLECT	31..146	CDD:214480	19/78 (24%)
		CLECT	182..315	CDD:214480	48/137 (35%)