Protein Alignment NCAN and Ncan

DIOPT Version :10

• Sequence 1: NP_004377.2
• Gene: NCAN / 1463
• HGNCID: 2465
• Length: 1321
• Species: Homo sapiens
• Sequence 2: NP_031815.2
• Gene: Ncan / 13004
• MGIID: 104694
• Length: 1268
• Species: Mus musculus
• Alignment Length: 1360
• Identity: 889/1360 - (65%)
• Similarity: 993/1360 - (73%)
• Gaps: 131/1360 - (9%)

Human     1 MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQP 65
            |||..|||.|||:|.:||.|||:|.||| |.|:|:||.|.|.|||.|:|||||||||||.|||||
Mouse     1 MGAGSVWASGLLLLWLLLLVAGDQDTQD-TTATEKGLRMLKSGSGPVRAALAELVALPCFFTLQP 64

Human    66 RPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPL 130
            |.|:.||.||||||||:|||||||||||||||||||||||.||||||||:|||.|||||||||||
Mouse    65 RLSSLRDIPRIKWTKVQTASGQRQDLPILVAKDNVVRVAKGWQGRVSLPAYPRHRANATLLLGPL 129

Human   131 RASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHL 195
            |||||||||||||:|||||||||.|||||||||||:|||||||||||||||||||||.|||||||
Mouse   130 RASDSGLYRCQVVKGIEDEQDLVTLEVTGVVFHYRAARDRYALTFAEAQEACRLSSATIAAPRHL 194

Human   196 QAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGG 260
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
Mouse   195 QAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRDPQELYDVYCFARELGG 259

Human   261 EVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRC 325
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 EVFYVGPARRLTLAGARAQCQRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRC 324

Human   326 GGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVREL 390
            ||||||||||||||||||||:|..|||||||||||.|:||||.|.|||||||||:||||||.|||
Mouse   325 GGPAPGVRTVYRFANRTGFPAPGARFDAYCFRAHHHTAQHGDSEIPSSGDEGEIVSAEGPPGREL 389

Human   391 EPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAP-- 453
            :|:|.|:||:.|||||||:||||.|...|...|..::||..|||.|.|||||:.|.||.|.||
Mouse   390 KPSLGEQEVIAPDFQEPLMSSGEGEPPDLTWTQAPEETLGSTPGGPTLASWPSSEKWLFTGAPSS 454

Human   454 ----SPSDMGAGTAASS--HTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPT 512
                ||||||....|::  .|:||||..|  |||||||||||:||||.||..|....|.||||||
Mouse   455 MGVSSPSDMGVDMEATTPLGTQVAPTPTM--RRGRFKGLNGRHFQQQGPEDQLPEVAEPSAQPPT 517

Human   513 SEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSIS 577
            ..|..|.|.|   .|.||...|.||.||||.||||||.|||||.|.:|.||..:|.|:::.||:.
Mouse   518 LGATANHMRP---SAATEASESDQSHSPWAILTNEVDEPGAGSLGSRSLPESLMWSPSLISPSVP 579

Human   578 GHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVAT--------SPDLPMMA 634
            .....|..:...||.||.:.|.|.|...|.|.  .||||.|.||....:        |||.|::|
Mouse   580 STDSTPSAKPGAAEAPSVKSAIPHLPRLPSEP--PAPSPGPSEALSAVSLQASSADGSPDFPIVA 642

Human   635 MLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPL--------SLTPTGQGG 691
            |||.||.|:||..|.:..           ....|.|||:       ||        ::.|...|.
Mouse   643 MLRAPKLWLLPRSTLVPN-----------MTPVPLSPAS-------PLPSWVPEEQAVRPVSLGA 689

Human   692 EAMPT------------TPESPRADFRETGETSPAQVNKAEHSSSSPWPSV-NRNVAVGFVPTET 743
            |.:.|            :..||.||..|...||..:..|  |..|.||.|: :.||.:..||::.
Mouse   690 EDLETPFQTTIAAPVEASHRSPDADSIEIEGTSSMRATK--HPISGPWASLDSSNVTMNPVPSDA 752

Human   744 ATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVP 808
                    ||.|:||||.|...|||||.||||::|...|..:..:|||..|.|.|:.:.||.:
Mouse   753 --------GILGTESGVLDLPGSPTSGGQATVEKVLATWLPLPGQGLDPGSQSTPMEAHGVAV-- 807

Human   809 KVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPL 873
                ::||.||.:.|.|..||::|....||.|...||      .|:.|...|..:|:
Mouse   808 ----SMEPTVALEGGATEGPMEATREVVPSTADATWE------SESRSAISSTHIAV-------- 854

Human   874 TTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGA--SVPPHQSSPLGKPAVPPGTPTAA 936
             |:.:..  |:|   ||.|:||:.||||:.|:..|.:...  ::|.|..|.|..|
Mouse   855 -TMARAQ--GMP---TLTSTSSEGHPEPKGQMVAQESLEPLNTLPSHPWSSLVVP---------- 903

Human   937 SVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMN 1001
             :.|.|||||||||..||..|||:||:||:::.:|.|:|.||.|:.||||||||:|..
Mouse   904 -MDEVASVSSGEPTGLWDIPSTLIPVSLGLDESDLNVVAESPSVKGFWEEVASGQEDP------- 960

Human  1002 AGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVN 1066
                   :||||||||||||||:.|||:||||||||:||||||||||||||||||||||||||||
Mouse   961 -------TDPCENNPCLHGGTCHTNGTVYGCSCDQGYAGENCEIDIDDCLCSPCENGGTCIDEVN 1018

Human  1067 GFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEE 1131
            ||:||||||||||.|||||||||||||||||||||||||||||||||:|||||:|||||||||||
Mouse  1019 GFICLCLPSYGGSLCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAERDCRRRAGHLTSVHSPEE 1083

Human  1132 HSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWN 1196
            |.|||||||||:|||||||.||||||||||||||:|||||.||||||||||||||||||||||||
Mouse  1084 HKFINSFGHENSWIGLNDRTVERDFQWTDNTGLQYENWREKQPDNFFAGGEDCVVMVAHESGRWN 1148

Human  1197 DVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSN 1261
            ||||||||||||||||||||||||||||||:|.||.||||||||||||:|||:||.|||||||:|
Mouse  1149 DVPCNYNLPYVCKKGTVLCGPPPAVENASLVGVRKIKYNVHATVRYQCDEGFSQHRVATIRCRNN 1213

Human  1262 GKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC 1321
            ||||||||:|.|||||||||||     |||.|.|||.|||.||||:||.||||||||:||
Mouse  1214 GKWDRPQIMCIKPRRSHRMRRH-----HHHPHRHHKPRKEHRKHKRHPAEDWEKDEGDFC 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCAN	NP_004377.2	Ig_Neurocan	41..162	CDD:409483	106/120 (88%)
		Ig strand A	41..44	CDD:409483	1/2 (50%)
		Ig strand A'	47..49	CDD:409483	1/1 (100%)
		Ig strand B	53..61	CDD:409483	7/7 (100%)
		Ig strand C	75..81	CDD:409483	5/5 (100%)
		Ig strand C'	90..93	CDD:409483	2/2 (100%)
		Ig strand D	111..116	CDD:409483	4/4 (100%)
		Ig strand E	122..128	CDD:409483	5/5 (100%)
		Ig strand F	136..143	CDD:409483	6/6 (100%)
		Ig strand G	153..162	CDD:409483	7/8 (88%)
		Link_domain_CSPGs_modules_1_3	160..254	CDD:239594	90/93 (97%)
		Link_domain_CSPGs_modules_2_4	261..356	CDD:239597	90/94 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..414		39/51 (76%)
		PHA03247	<421..964	CDD:223021	228/581 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..479		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..513		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..579		26/46 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..731		18/69 (26%)
		O-glycosylated at one site	708..712		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	820..844		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..955		29/80 (36%)
		EGF	1012..1042	CDD:394967	25/29 (86%)
		EGF_CA	1046..1082	CDD:238011	33/35 (94%)
		CLECT	1088..1211	CDD:470576	115/122 (94%)
		CCP	1215..1271	CDD:153056	48/55 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1321		33/45 (73%)
Ncan	NP_031815.2	Ig	40..161	CDD:472250	106/120 (88%)
		Ig strand B	54..58	CDD:409483	3/3 (100%)
		Ig strand C	74..78	CDD:409483	3/3 (100%)
		Ig strand E	122..126	CDD:409483	3/3 (100%)
		Ig strand F	136..141	CDD:409483	4/4 (100%)
		Ig strand G	154..157	CDD:409483	2/2 (100%)
		Link_domain_CSPGs_modules_1_3	159..253	CDD:239594	90/93 (97%)
		Link_domain_CSPGs_modules_2_4	260..355	CDD:239597	90/94 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..391		23/27 (85%)
		PHA03247	<400..851	CDD:223021	204/497 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..442		19/35 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	472..540		40/72 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..630		19/57 (33%)
		EGF	964..994	CDD:394967	25/29 (86%)
		EGF_CA	998..1034	CDD:238011	33/35 (94%)
		CLECT	1040..1163	CDD:470576	115/122 (94%)
		CCP	1167..1224	CDD:153056	48/56 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1228..1268		32/44 (73%)