DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VCAN and lectin-22C

DIOPT Version :9

Sequence 1:	NP_004376.2	Gene:	VCAN / 1462	HGNCID:	2464	Length:	3396	Species:	Homo sapiens
Sequence 2:	NP_001137766.1	Gene:	lectin-22C / 7354375	FlyBaseID:	FBgn0259230	Length:	263	Species:	Drosophila melanogaster

Alignment Length:	157	Identity:	40/157 - (25%)
Similarity:	67/157 - (42%)	Gaps:	25/157 - (15%)

- Green bases have known domain annotations that are detailed below.

Human  3148 TFRCLCLPSYVGAL----CEQDTETCDYGWHKFQGQCYKYF--AHRRTWDAAERECRLQGAHLTS 3206
            |.|..|:...:.||    .|..|:....|:.:. |..|.|.  ...:.|..|.:.||..|.||..
  Fly   110 TERLNCMEGILSALEKTVLEVKTKIKYLGFEQI-GSKYYYIEKVSEKNWSTASKTCRNMGGHLAD 173

Human  3207 ILSHEEQMFV--NRVGHDYQWIGLNDKMFEHDFRWTDGST------LQYENWRPNQPDSFFSAGE 3263
            |....:...:  |.....:.|:|:||  .:|:.::....|      |::.:.||:|.|:.
  Fly   174 IKDEADLAAIKANLKEDTHYWLGIND--LDHEGKFLSMPTGKQTTFLKWASGRPSQLDTL----- 231

Human  3264 DCVVIIWHENGQWNDVPCNYHLTYTCK 3290
            :||.:.   ||:..|.||:|...:.|:
  Fly   232 NCVFLY---NGEMYDYPCHYTFRFICQ 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VCAN	NP_004376.2	IG_like	29..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		GAG-alpha (glucosaminoglycan attachment domain)	348..1335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1316
		GAG-beta	1336..3089
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1510..1539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1717..1737
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1759..1789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1962..1994
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2168..2188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2371..2396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2445..2473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2493..2518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2834..2856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2881..2905
		EGF_CA	3091..3125	CDD:238011
		EGF_CA	3127..3163	CDD:238011	5/18 (28%)
		CLECT_CSPGs	3169..3292	CDD:153058	33/132 (25%)
		CCP	3296..3352	CDD:153056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3371..3396
lectin-22C	NP_001137766.1	CLECT	146..255	CDD:153057	30/118 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4956
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940