Protein Alignment TTBK2 and Asator

DIOPT Version :10

• Sequence 1: XP_005254228.1
• Gene: TTBK2 / 146057
• HGNCID: 19141
• Length: 1250
• Species: Homo sapiens
• Sequence 2: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Alignment Length: 1197
• Identity: 357/1197 - (29%)
• Similarity: 513/1197 - (42%)
• Gaps: 261/1197 - (21%)

Human    75 KME-------SGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQIL 132
            |||       .||:|||||||||||||||||||||||:|||:|||:|.||.|::|||||||.|||
  Fly   214 KMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQIL 278

Human   133 ESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVR 197
            ::|||||||||||||||||||::||.|..||:.||||||||||:|...|:||.|||.||||||||
  Fly   279 KAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVR 343

Human   198 YASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFS 262
            |||||||||||||||||||||||||||||.|||||||||||||||..||:||||::|||||.:..
  Fly   344 YASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLK 408

Human   263 IFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGND--GSLTTTTTSTTP---- 321
            .||:||.||.|..:|||.:|..:|:..:|..||.||||:||||..:.  |:::.|...:.|
  Fly   409 QFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSD 473

Human   322 QLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEK 386
            .:|..:|...:..:||:..  :.:|:..:........:|     |:.:.
  Fly   474 YMHGNITQMTVAASNASGT--EYIRKRAEIETAHITATD-----PLNIK---------------- 515

Human   387 DVWEEMDANKNKIKLG-ICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPD------RDIP 444
               |::|.|.|...|. ..|.:.|....||.|....|..|.|  ::.:|.:|...      :..|
  Fly   516 ---EKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNITSKG--LQQQSTLTNSQVAIANIQSAP 575

Human   445 LVRKLRSIHSFELE-----KRLTLEPKPDTDK--FLETCLEKMQKDTSAGKESILPALLHKPCVP 502
            .:.:...:...:||     |.:|::|..:.|.  ....|:.: ||...|..:     ::.:..:.
  Fly   576 SMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCIFE-QKHVEANDD-----IVGRASLS 634

Human   503 AVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIA-VNLSSCKQEID-SKEWVIVDKEQ 565
            .|.:     ||..: :...:.|..||...|..|..:|...: ||.|:.:|:.. .:..|:.....
  Fly   635 GVEQ-----HYKSQ-IKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPM 693

Human   566 DLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASP---QDEKLQLGPWAENDHLKKETSGVVLALS 627
            .:.|..:.....|:.:.....::| ......|:|   .....:.|    :.|      |.:..|:
  Fly   694 SVHDLPSGGGHSHQVSDLSGKQDP-YAATSNAAPIGINSSSTKFG----SQH------GQIFGLA 747

Human   628 AEGPPTAASEQYTDRLELQP-GAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFH 691
            |..|....|...|:   |:| .:|||.|.:..| :..|...|..||    |.|||...|.
  Fly   748 AMPPINRRSATSTN---LRPSSSASQRINSGST-IGGAVGNGSNTA----RSSVAGDHSV----- 799

Human   692 CGQQPEKKDLQPMEPTVELYSPRENFSGL-VVTEGEPPSGGSRT---DLGLQID----------H 742
                           |.......||.|.| .||:     ||:.|   ....|.|          :
  Fly   800 ---------------TQFALIDDENVSALQQVTK-----GGALTLASQWKSQFDDSEDTTDNEWN 844

Human   743 IGHDMLPNIRESNKSQDLGP----KELPDHNRLVVREFENLPGETEEK---------------SI 788
            ..|.:.||:.:..|.....|    |..|.|......:..|.|||.:.:               ::
  Fly   845 REHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPPGEAKGRPKRYTLNITGIENYEAL 909

Human   789 LLESDN------EDEKLSRGQHCIEISSLPGDLVIVEKD-------HSATTEPLDVTKTQTFSV- 839
            .:...|      ....|.:|.....:.....|..:...|       ....:|...:.:..|.||
  Fly   910 RISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPSTSSVL 974

Human   840 ---VPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGD 901
               :|:..|.:..::|.:...|...||        ....:..:..|.|. ||..|..:|     |
  Fly   975 RNRLPSPFKKDSALQLNSTNDSLDKSR--------HRNSLPNVSVNDIF-DDLQMKLNL-----D 1025

Human   902 LSTFLHQ-----EGKRE-KITPR-----NGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLA 955
            |.:.:.:     .|:.| ::.|:     :..:::.........||..:        .|.......
  Fly  1026 LGSAIQENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANE--------GHDHSDQAV 1082

Human   956 QEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPF 1020
            ...|....:|:.::...|.:.|....|.  :...|:|...|.....|:..:||   ||....||
  Fly  1083 NNCDEMEATSAVIAFPNKSISKIMSPPG--RDATEERTGASLCSLYSAGVNKL---KLNGNTAP- 1141

Human  1021 CEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIP----RPVSWVNTDQVNSS--TSSQF 1079
                 .|.|.:.:.|......:|..|  |:::   .||||    :..||...|.:::|  ..|..
  Fly  1142 -----RTQFKKGSTDGFGENESEFDF--PLLN---PSKIPVRQSKCASWAGADFISASKPLESAE 1196

Human  1080 FPRPPPGKP------------PTR------------------PGVEARLRRYKVLGSSNSDSDLF 1114
            .|:..|..|            |.|                  ||:  |.||....|...:|...
  Fly  1197 VPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISDLTPGL--RRRRESTEGKYVTDPTQ- 1258

Human  1115 SRLAQILQNGSQKPRSTTQCKSPGSPH 1141
                  |....|:|||.|..::.|.|:
  Fly  1259 ------LPLKFQRPRSRTSSRTRGIPN 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTBK2	XP_005254228.1	Protein Kinases, catalytic domain	75..287	CDD:473864	163/218 (75%)
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	163/218 (75%)