Protein Alignment TTBK2 and ball

DIOPT Version :10

• Sequence 1: XP_005254228.1
• Gene: TTBK2 / 146057
• HGNCID: 19141
• Length: 1250
• Species: Homo sapiens
• Sequence 2: NP_651508.1
• Gene: ball / 43228
• FlyBaseID: FBgn0027889
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 147/657 - (22%)
• Similarity: 234/657 - (35%)
• Gaps: 216/657 - (32%)

Human     3 CQIGEVN-------NPLGCQDTLFYSEVNFVSVEATVEVKWKPPLGTGCLCSCSTISVYCNEWGR 60
            |::||.|       .|.| ...||. |::|....|.:|                .|..:..:.|.
  Fly    65 CKVGEKNYDAVVKCEPHG-NGPLFV-EMHFYLRNAKLE----------------DIKQFMQKHGL 111

Human    61 RAAGYPECWNPSERKMESGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTL 125
            ::.|.|..       :.:|...|       ..::..::||...|.:|... ..|:.......|..
  Fly   112 KSLGMPYI-------LANGSVEV-------NGEKHRFIVMPRYGSDLTKF-LEQNGKRLPEGTVY 161

Human   126 RLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRP-PRAV 189
            ||..|:|:..:.:||.|::|.|:|.:|..:|.......:.|::|||||..|..  ||.:| |:.:
  Fly   162 RLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVT--GDFKPDPKKM 224

Human   190 AGFRGTVRYASINAHRNREMG---RHDDLWSLFYMLVEFVVGQLPW------------RKIKD-- 237
              ..||:.|.|.:||    :|   |..||..|.|.|:|::..:|||            :|.|:
  Fly   225 --HNGTIEYTSRDAH----LGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAF 283

Human   238 KEQVG-SIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPF 301
            .:.:| |:|     .|..|.:||....|:.::|.|.:..:|||....|.|.:::|...:..:...
  Fly   284 MDNIGESLK-----TLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDL 343

Human   302 DWE---KTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGEN 363
            |::   :|.::.:|:...||           .|.....|..|...:|..:.||
  Fly   344 DFKMKPQTSSNNNLSPPGTS-----------KAATARKAKKIDSPVLNSSLDE------------ 385

Human   364 GIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLG- 427
                     |:..|       |.|  ||                 |||.||.:.......||..
  Fly   386 ---------KISAS-------EDD--EE-----------------EEEKSHRKKTAKKVTPSARN 415

Human   428 ---SPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKE 489
               ||::..::.:.|.                 :||:..|||                  |..:|
  Fly   416 AKVSPLKRVADSSPPS-----------------QKRVKTEPK------------------STPRE 445

Human   490 SILPALLHKP-CVPAVSRTDHIWHYDEEYLPDASKPASAN-----TPEQADGGGSNGFIAVNLSS 548
            ...|....|| ..|..|        .:...|.|::..:.|     :|..:..|...|...:|...
  Fly   446 RATPKASPKPRSTPKAS--------PKPQTPTAARLRTPNAKINFSPSISLRGRPGGKTVINDDL 502

Human   549 CKQEIDSKEW-------------VIVD---KEQDLQDFRTNEAVGHKTTGS-----PSDEEPEVL 592
            ..|....|.:             |||:   |::..||..|  ||..:|..|     .|.:|
  Fly   503 TPQPRSKKTYEFNFELDVSMDANVIVNVKRKKKADQDKAT--AVDSRTPSSRSALASSSKE---- 561

Human   593 QVLEASP 599
               ||||
  Fly   562 ---EASP 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTBK2	XP_005254228.1	Protein Kinases, catalytic domain	75..287	CDD:473864	64/230 (28%)
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	80/308 (26%)
		PRK11633	<410..>471	CDD:236940	18/103 (17%)