Protein Alignment TTBK2 and bsd

DIOPT Version :10

• Sequence 1: XP_005254228.1
• Gene: TTBK2 / 146057
• HGNCID: 19141
• Length: 1250
• Species: Homo sapiens
• Sequence 2: NP_610733.1
• Gene: bsd / 36302
• FlyBaseID: FBgn0027504
• Length: 1004
• Species: Drosophila melanogaster
• Alignment Length: 807
• Identity: 160/807 - (19%)
• Similarity: 264/807 - (32%)
• Gaps: 296/807 - (36%)

Human    64 GYP-ECWNPSERKMESGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRL 127
            ||| |....|:...||..:....||.....   ..|:.:.:...:|..:::      .:||  |.
  Fly   427 GYPKETAENSDESPESSDNESDEFIPPSSR---RSVIKRGRSAQIATPKKT------PVST--RA 480

Human   128 GRQILESI-------ESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRP 185
            .||  |.:       :.:.|.|..|.|..|:.:..  .|:.....:::|||||.:|.:. |..||
  Fly   481 SRQ--EKVKKEPNGDQKLRSRGSKHLDNNPTEYKF--LPTEEEHVFLIDFGLASKFQDR-GVHRP 540

Human   186 -----PRAVAGFRGTVRYASINAHRNREMGRH---DDLWSLFYMLVEFVVGQLPWRKI---KDKE 239
                 .||   ..||:.:.|.:||    :|.|   .||..|.|.|:.:..|.|||:.:   :.:|
  Fly   541 FIMDQRRA---HDGTLEFTSRDAH----LGAHSRRSDLECLGYNLLYWSEGYLPWKDVAQQQQQE 598

Human   240 QVGSIKERY--DHRLML-----KHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIE 297
            :|...||.:  |...||     |.:|.....||..|..|.|..:|:|:....:|....:..|.
  Fly   599 KVHRAKELFMTDVPEMLRQFYGKQVPKYLGEFLLQIGQLAYQERPNYERYRKIFKREYQRLGY-- 661

Human   298 SDPFDWEKTGNDGSLTTTTTSTTP----------QLHTRLTPAAIGIANATPIPGDLLRENT-DE 351
             ||.....:..:  :..|..||..          :|:.:   ||:.:          :|.:| ..
  Fly   662 -DPCQMRLSSEE--ILRTCVSTKDVVDGSKCDIFELNNK---AAVNV----------MRNSTLST 710

Human   352 VFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQ 416
            .|.:..|::       .|||..|.........::|..|.|
  Fly   711 PFQEHSLTN-------RVSPKNLRSKSNKKTTKKKFSWAE------------------------- 743

Human   417 ANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFE-------LEKRL--TLEPKPDTDKF 472
                           |.|:  .||:    :.:.|::..||       ||.||  ..|.|| |...
  Fly   744 ---------------VLSQ--DPDQ----IARERAVKEFEREETICPLESRLPRRYEGKP-TYAI 786

Human   473 LETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGG 537
            |:  :|:.:::.....:.                     |.:||             .|.||.
  Fly   787 LD--MEQRRREKGLVVQE---------------------HIEEE-------------EEDADE-- 813

Human   538 SNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDE 602
                        ..|.:::|.:.:|:|:|          |.....:..::|.:  :.:|.|..
  Fly   814 ------------DDEEENQEAMDIDQEED----------GEAADSAEGEDESD--RSMEGSDC-- 852

Human   603 KLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQ----------------PGAAS 651
                     :||.:|.         |.|.|...|.:.|...:.|                ||..|
  Fly   853 ---------SDHSQKR---------ARGRPKGTSRKQTTSRQAQPHQNQPPVKVHRGVGRPGKNS 899

Human   652 QFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPREN 716
            ..:.....::.:.:        |.|..:|||.:.     .|..:.|...|
  Fly   900 GVVKLAAGAVSKNR--------TTPLSAVASNKR-----GCATRKENSTL--------------- 936

Human   717 FSGLVVTEGEPPSGGSRTDLGL---QIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFEN 778
              .....|||......||...|   :..|..||     .|:|.|            .|||   :|
  Fly   937 --ASATGEGERKLKSGRTRRALYKTEPKHGEHD-----AENNSS------------LLVV---QN 979

Human   779 LPGETEEKSILLESDNEDEKLSRGQHC 805
            |.||.::::    :..:...:...:||
  Fly   980 LYGEYDDEN----NYGKGRSVHSSRHC 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTBK2	XP_005254228.1	Protein Kinases, catalytic domain	75..287	CDD:473864	61/236 (26%)
bsd	NP_610733.1	Protein Kinases, catalytic domain	112..>286	CDD:473864
		Protein Kinases, catalytic domain	<517..652	CDD:473864	43/142 (30%)