Protein Alignment TTBK2 and CG2577

DIOPT Version :10

• Sequence 1: XP_005254228.1
• Gene: TTBK2 / 146057
• HGNCID: 19141
• Length: 1250
• Species: Homo sapiens
• Sequence 2: NP_572794.1
• Gene: CG2577 / 32188
• FlyBaseID: FBgn0030384
• Length: 344
• Species: Drosophila melanogaster
• Alignment Length: 359
• Identity: 94/359 - (26%)
• Similarity: 149/359 - (41%)
• Gaps: 99/359 - (27%)

Human    74 RKMESGKDHVCRFIGCG--------------------------RNDRFNY--------------- 97
            |::..|...|.|.||||                          |:.:.||
  Fly    10 REVRIGNYKVVRKIGCGSFGDIYLGIYIHSGERVAIKVESSKVRHPQLNYERRIYRALRPAHGLP 74

Human    98 -------------VVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIK 149
                         :||.|.|.:|..|.:...| .|||.|.|.|..|:|..:|.:|:.||||||||
  Fly    75 RIRYFHKEEHYQAMVMDLLGPSLERLFQFCER-AFTIKTVLLLAEQMLRRVEYVHNRGFLHRDIK 138

Human   150 PSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVR-PPRAVAGFRGTVRYASINAHRNREMGRHD 213
            |.||.|| ..:..::.|::||||::::.:....|. |.|......||.|||||.||...|..|.|
  Fly   139 PDNFLMG-LGTMSKQVYLIDFGLSKKYLDITTGVHIPYREERSLTGTARYASIGAHAGVESARRD 202

Human   214 DLWSLFYMLVEFVVGQLPWRKIKDK------EQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLD 272
            |:.::.|:|:.|..|.|||:.:|..      |::...|......::.:..|.||:::|::...:.
  Fly   203 DMVAVGYVLMYFNRGSLPWQDLKASTKQQKYERIHEKKISVSIEVLCEGFPCEFTMYLNYCRGMG 267

Human   273 YFTKPDYQLLTSVF---DNSIKTF-GVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIG 333
            ::.||:|..:..:|   .|.:... |:|    :||:..    .:....|...|.:..|:.|
  Fly   268 FYDKPNYDFICRMFRMLRNGLNLRPGLI----YDWDML----MMKFHNTQKNPGIGMRVFP---- 320

Human   334 IANATPIPGDLLRENTDEVFPDEQLSDGENGIPV 367
                                |.::..||.:|.|:
  Fly   321 --------------------PKQKEDDGISGEPI 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTBK2	XP_005254228.1	Protein Kinases, catalytic domain	75..287	CDD:473864	79/275 (29%)
CG2577	NP_572794.1	STKc_CK1	16..281	CDD:270918	77/266 (29%)