Protein Alignment ADRA1D and Oamb

DIOPT Version :10

• Sequence 1: NP_000669.1
• Gene: ADRA1D / 146
• HGNCID: 280
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 718
• Identity: 186/718 - (25%)
• Similarity: 263/718 - (36%)
• Gaps: 301/718 - (41%)

Human    99 VGVFLAAFI-LMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162
            :.:.:..|| ::.:.||.|||.:|.|:..|::|||:|||||||||||:...|||||||.||...|
  Fly    22 ISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVW 86

Human   163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVV 227
            .||..:|.:|.||||..||||||:||.||:||||.|...:.||:||:.:||.:::|.:||::..:
  Fly    87 IFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFI 151

Human   228 SVGPLLGWKE--------------------------------------------PVPP------- 241
            ...||:|||:                                            |.||
  Fly   152 CFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNA 216

Human   242 ----DERF--------------------------------------------------------- 245
                |..|
  Fly   217 YNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISG 281

Human   246 -----CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERG-------- 297
                 |.:|.:.||.::|::.|||:||.|::..|.|:|..|..|||::..|.|..:|
  Fly   282 SCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRF 346

Human   298 KASEVVLRIHCRGAAT------------------------------------------------- 313
            :...:.|||| ||..:
  Fly   347 EEQRLTLRIH-RGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPS 410

Human   314 ------------------------------GADG-------------AHGMRSA----------- 324
                                          |.:|             .||:.|:
  Fly   411 SENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLPE 475

Human   325 -------------KGHT-------FRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFF---F 366
                         .||:       .|.::..::.:|..|.||||||||:||:|:.||.|||   .
  Fly   476 LARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYI 540

Human   367 VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLL-RCQCRRR------ 424
            :.|    |.|......:|.|:|||||.||.|||:||...|::|:.||.|:: ||.|.|:
  Fly   541 IRP----FCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKS 601

Human   425 -RRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRR 488
             ||...:..:   ..||.|..:....|..|..               |.......||..... |.
  Fly   602 SRRGSDMSAI---RIRARTPSITPSAAAHSFG---------------DESELHHSEMSNDPRXRS 648

Human   489 KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEG 553
            ..||:..: ..||..|:  |.|:..|..:.|.:      ..|.||  .|.|||.|.|       .
  Fly   649 FGPSSSSQ-SSLGGLRK--TSLKVPVYEICHPL------VMETAC--YSYVEATSDG-------S 695

Human   554 ATC 556
            |:|
  Fly   696 ASC 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77
		7tmA_alpha1D_AR	97..413	CDD:320450	148/565 (26%)
		TM helix 1	98..124	CDD:320450	8/25 (32%)
		TM helix 2	131..157	CDD:320450	20/25 (80%)
		TM helix 3	169..199	CDD:320450	20/29 (69%)
		TM helix 4	211..234	CDD:320450	7/22 (32%)
		TM helix 5	251..280	CDD:320450	12/28 (43%)
		TM helix 6	341..371	CDD:320450	18/32 (56%)
		TM helix 7	381..406	CDD:320450	14/24 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..488		5/43 (12%)
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	148/565 (26%)
		TM helix 1	22..48	CDD:320191	8/25 (32%)
		TM helix 2	55..81	CDD:320191	20/25 (80%)
		TM helix 3	93..123	CDD:320191	20/29 (69%)
		TM helix 4	135..158	CDD:320191	7/22 (32%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	17/29 (59%)
		TM helix 7	551..576	CDD:320191	14/24 (58%)