DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arhgdig and RhoGDI

DIOPT Version :9

Sequence 1:	NP_032139.1	Gene:	Arhgdig / 14570	MGIID:	108430	Length:	225	Species:	Mus musculus
Sequence 2:	NP_001262080.1	Gene:	RhoGDI / 40179	FlyBaseID:	FBgn0036921	Length:	201	Species:	Drosophila melanogaster

Alignment Length:	203	Identity:	85/203 - (41%)
Similarity:	121/203 - (59%)	Gaps:	9/203 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 LADKDGESTP---SDEVLDEIVPEYQAPGKKSMLAIWQLDPGDVSLVKYKQALLGPLPP---IMD 85
            :|:.:.:..|   .|:|.|   ..||||.:|::..|...|..|.||.:||:||||....   |::
  Fly     1 MAETETKHHPEHHDDDVHD---ANYQAPPEKTIEEIMAADQEDESLRRYKEALLGAAQTEKIIVE 62

Mouse    86 PSLPNVQVTRLTLLTEQAPGPIIMDLTGDLDALKNQVFVLKEGIEYKVKITFKVNKEIVSGLKCL 150
            |:.|...:.:...|..:....:.:||||||..||.|:||:|||::|||:|.|.|.:|||.|||.:
  Fly    63 PNDPRKVIVKKLALVVEGRDDMELDLTGDLSQLKKQLFVIKEGVQYKVRIDFIVQREIVHGLKYV 127

Mouse   151 HHTYRRGLRVDKAIFMVGSYGPRAQEYEFVTSVEEAPRGALARGLYVVRSLFTDDDRLNHLSWEW 215
            ..|.|.|:.|||...|||||.|:.:...::|..||||.|..:||.|.|.|:|||||:..||.|:|
  Fly   128 QKTSRLGVNVDKMKHMVGSYPPKKEIQFYLTPAEEAPSGTFSRGTYSVSSVFTDDDKHIHLEWDW 192

Mouse   216 HLHVCQDW 223
            ...:.:||
  Fly   193 TFEIKKDW 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arhgdig	NP_032139.1	Rho_GDI	42..222	CDD:307981	79/182 (43%)
RhoGDI	NP_001262080.1	Rho_GDI	14..199	CDD:280310	81/187 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837035
Domainoid	1	1.000	195	1.000	Domainoid score	I3138
eggNOG	1	0.900	-	-		E1_KOG3205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3780
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54245
OrthoDB	1	1.010	-	-		D1265661at2759
OrthoFinder	1	1.000	-	-		FOG0001289
OrthoInspector	1	1.000	-	-		otm42349
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2126
SonicParanoid	1	1.000	-	-		X792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.900