Protein Alignment CSNK1E and CG12147

DIOPT Version :10

• Sequence 1: NP_001885.1
• Gene: CSNK1E / 1454
• HGNCID: 2453
• Length: 416
• Species: Homo sapiens
• Sequence 2: NP_649536.1
• Gene: CG12147 / 40651
• FlyBaseID: FBgn0037325
• Length: 477
• Species: Drosophila melanogaster
• Alignment Length: 417
• Identity: 188/417 - (45%)
• Similarity: 257/417 - (61%)
• Gaps: 38/417 - (9%)

Human     2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIP 66
            |:.|..||||.::||:||||:::....:...|:||||||....|||.|..|::.|.::|||:|||
  Fly    61 EIIVAGKYRLLKRIGNGSFGELFQAEGLKYHEKVAIKLESSTVKHPLLPREARIYGILQGGLGIP 125

Human    67 SIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKP 131
            .:|....||.||||||:||||:||||.|.|||.||:||.|:||||:::|:|.:|.:.|||||:||
  Fly   126 HVKHYATEGAYNVMVMDLLGPTLEDLLNLCSRSFSMKTTLMLADQILARVELLHRRCFIHRDIKP 190

Human   132 DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDL 196
            |||||||.:....||:||||||||:...||.:||.|.||::|.|||||||:..|.. ||||||||
  Fly   191 DNFLMGLNRHQTQVYMIDFGLAKKFYSLRTQKHIGYTENRDLVGTARYASVRAHYA-EQSRRDDL 254

Human   197 ESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFD 261
            ||:||:|:||..|.|||||::|.::.||||:|:|.|.:.|::.||.|.|.||..||.:||.|.|.
  Fly   255 ESVGYLLLYFQRGRLPWQGIRAQSQAQKYEKIAEYKANIPLQQLCSGLPVEFFMYLKYCRKLHFA 319

Human   262 DKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRER-REHER----------EE 315
            :||||.||:|||:.||..|....|::|||.:||   ..:||...::: ||.:|          |.
  Fly   320 EKPDYVYLQQLFKVLFRNQYKVCDFLFDWVVLK---RESPEQQSQQKGRERDRGGKRNVVVQKER 381

Human   316 RMGQLRGSAT---RALPPGPPTGATANRLRSAAEPVASTP---------------ASRIQPAGNT 362
            ...:.|.|.|   |....|.......|...:..:|....|               ..|:|.....
  Fly   382 HRNKDRDSDTQRCRIKNGGDLLEIEENESTTGEDPNEDKPQKKHGKACSCSYHLQKKRLQDRDRR 446

Human   363 SP----RAISRVDRERKVSMRLHRGAP 385
            :|    |.|...::|:::.:.| ||:|
  Fly   447 APLMTERRILSGEQEQELELEL-RGSP 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1E	NP_001885.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	156/273 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..416		24/118 (20%)
CG12147	NP_649536.1	STKc_CK1	67..331	CDD:270918	151/264 (57%)