Protein Alignment CSNK1E and CkIalpha

DIOPT Version :10

• Sequence 1: NP_001885.1
• Gene: CSNK1E / 1454
• HGNCID: 2453
• Length: 416
• Species: Homo sapiens
• Sequence 2: NP_511140.1
• Gene: CkIalpha / 32221
• FlyBaseID: FBgn0015024
• Length: 337
• Species: Drosophila melanogaster
• Alignment Length: 316
• Identity: 210/316 - (66%)
• Similarity: 254/316 - (80%)
• Gaps: 7/316 - (2%)

Human     2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIP 66
            |:.||.|||:.||||||||||||||.:|.||||||||:|....:||||..|:|.|:::.||||.|
  Fly    13 EIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFP 77

Human    67 SIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKP 131
            .|:..|.|.::|.:||:|||||||||||||:|.|::||||:|.||||.|:||||.|.|||||:||
  Fly    78 RIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKP 142

Human   132 DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDL 196
            ||||||:|:..|.:::||||||||:||..|..||.|||:|||||||||||||.|||||||||||:
  Fly   143 DNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDM 207

Human   197 ESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFD 261
            ||||||:||||.|.|||||:||.||:||||:||||||||||||||||.|:|||.|||:||||||:
  Fly   208 ESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFE 272

Human   262 DKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK---FGAARNP----EDVDRERRE 310
            ::|||.|||||||.||......|||::||.|||   .....||    |.:|:::.:
  Fly   273 EQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEK 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1E	NP_001885.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	195/273 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..416		3/14 (21%)
CkIalpha	NP_511140.1	Protein Kinases, catalytic domain	19..284	CDD:473864	190/264 (72%)