Protein Alignment CSNK1D and HRR25

DIOPT Version :10

• Sequence 1: XP_005256393.1
• Gene: CSNK1D / 1453
• HGNCID: 2452
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_015120.1
• Gene: HRR25 / 855897
• SGDID: S000006125
• Length: 494
• Species: Saccharomyces cerevisiae
• Alignment Length: 493
• Identity: 224/493 - (45%)
• Similarity: 303/493 - (61%)
• Gaps: 84/493 - (17%)

Human     1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGI 65
            |:||||.::|:|||||||||||||.||::.:|||||||||.::::||||..||::|:.:.|||||
Yeast     1 MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGVGI 65

Human    66 PTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVK 130
            |.|||.|.||:||.||::|||||||||||:|.|:||.|||::||.||..||:|||.::|||||:|
Yeast    66 PFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIK 130

Human   131 PDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD 195
            |||||||:|::|:.|::|||||:|||||..||:||||||||:|||||||||:|||||||||||||
Yeast   131 PDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDD 195

Human   196 LESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRF 260
            ||||||||:||..||||||||||.||:|||:||.|||::..:|.||.|.|.||..|:.:|::|:|
Yeast   196 LESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKF 260

Human   261 DDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKF-------------------------GASRA 300
            |:||||.:|.:||::|..:..:..|::|||.||::                         .||.:
Yeast   261 DEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQRDLLIEKGDLNANSNAASASNS 325

Human   301 ADDA------------------------ERERRDREERLRHS---RNPATRGLPSTASGRL-RGT 337
            .|:.                        |.:.....|.::..   .|.|...||......| :|.
Yeast   326 TDNKSETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTILNNNAASSLPEELLNALDKGM 390

Human   338 QEV-----------APPTP------LTPTSHTANTSPRPV------SGMERERKVSMRLHRGA-- 377
            :.:           :.|.|      ..|.....|..|.|:      ...|::::|.|...|..
Yeast   391 ENLRQQQPQQQVQSSQPQPQPQQLQQQPNGQRPNYYPEPLLQQQQRDSQEQQQQVPMATTRATQY 455

Human   378 PVNISSSDLTGRQDT----SRMSTSQVGAELPGGR--W 409
            |..|:|::....|.:    .|.:..|...:.|.|:  |
Yeast   456 PPQINSNNFNTNQASVPPQMRSNPQQPPQDKPAGQSIW 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1D	XP_005256393.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	183/273 (67%)
HRR25	NP_015120.1	Protein Kinases, catalytic domain	8..282	CDD:473864	183/273 (67%)