Protein Alignment RDH12 and Rdh1

DIOPT Version :10

• Sequence 1: NP_689656.2
• Gene: RDH12 / 145226
• HGNCID: 19977
• Length: 316
• Species: Homo sapiens
• Sequence 2: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 155/305 - (50%)
• Similarity: 198/305 - (64%)
• Gaps: 20/305 - (6%)

Human    22 IRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVD 86
            ::::..||....:....|||.::||||||||||||.|:|.||..||:||||:.:.|.|..:|..:
  Fly    26 LKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKE 90

Human    87 TKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGH 151
            |.|..:..|:||||...|||.|.:||..|:.:||:||||||||.||.:.|.||:|..|||||:||
  Fly    91 TNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYELQLGVNHIGH 155

Human   152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAK 216
            ||||.|||:.||.|||:|:|.|||:||..|.|...||.|||.|..|.||..||||||||||||||
  Fly   156 FLLTNLLLDVLKNSAPSRIVVVSSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAK 220

Human   217 RLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFS-------------PFVKTAREGAQTSLHC 268
            ||:|:|||..|:|||||.:||.|:       |..|.             |.:||.:.|||||::.
  Fly   221 RLEGSGVTVNALHPGVVDTELARN-------WAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYA 278

Human   269 ALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
            ||...|:.:||.||||||...|:..|.::|.|:.||..|.:..|:
  Fly   279 ALDPELKNISGLYFSDCKPKPVASGALDDKVAKFLWAESEKWTGL 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	151/280 (54%)
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	151/280 (54%)