Protein Alignment RDH12 and CG30491

DIOPT Version :10

• Sequence 1: NP_689656.2
• Gene: RDH12 / 145226
• HGNCID: 19977
• Length: 316
• Species: Homo sapiens
• Sequence 2: NP_610306.1
• Gene: CG30491 / 35704
• FlyBaseID: FBgn0050491
• Length: 331
• Species: Drosophila melanogaster
• Alignment Length: 310
• Identity: 164/310 - (52%)
• Similarity: 205/310 - (66%)
• Gaps: 17/310 - (5%)

Human     4 TLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYI 68
            |.||  :||         ::....||.........|||.::|||||||||||.||:|.||..||:
  Fly    21 TTGL--AFF---------VKDLMQGGQFTKETNETGKVFIVTGANTGIGKETVREIAKRGGTVYM 74

Human    69 ACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPY 133
            |||::.|.|.|..||.::|||..|..|:.||:..:|||.|...|..|::.||:||||||||.||.
  Fly    75 ACRNLKKCEEAREEIVLETKNKYVYCRQCDLASQESIRHFVAAFKREQEHLHVLINNAGVMRCPR 139

Human   134 SKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGF 198
            |.|:||.|..|||||:||||||.|||:.||.|:|:|:|||||:||..|:|...||.|:|.|..|.
  Fly   140 SLTSDGIELQLGVNHMGHFLLTNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGK 204

Human   199 AYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLL------CLLWRLFSPFVKT 257
            ||..||||||||||||||||:||.||..|:|||||.:|::||....      ..:..||.|||||
  Fly   205 AYSQSKLANVLFTRELAKRLEGTNVTANALHPGVVDTEIIRHMGFFNNFFAGLFVKPLFWPFVKT 269

Human   258 AREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVS 307
            .|.||||||:.||...||.::|:||||||...::|.|.:.:||:.||.||
  Fly   270 PRNGAQTSLYVALDPELEKVTGQYFSDCKLKEMAPAATDTQTAKWLWAVS 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	155/273 (57%)
CG30491	NP_610306.1	Rossmann-fold NAD(P)(+)-binding proteins	45..319	CDD:473865	155/273 (57%)