Protein Alignment CSNK1A1 and dco

DIOPT Version :10

• Sequence 1: NP_001020276.1
• Gene: CSNK1A1 / 1452
• HGNCID: 2451
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_524602.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 366
• Identity: 219/366 - (59%)
• Similarity: 260/366 - (71%)
• Gaps: 57/366 - (15%)

Human    10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIP 74
            |..||.||:|.|||||||||||||...|..|||||:|||..:.:||||..|||.||.:|||:|||
  Fly     2 ELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIP 66

Human    75 HIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKP 139
            .|.|.|.|.||||:||:|||||||||||||||||::||||:|||||||||:|:|:::||||||||
  Fly    67 RIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKP 131

Human   140 DNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYR 204
            ||||||:|:                           .| |.:::||||||||:||.|:.:|||||
  Fly   132 DNFLMGLGK---------------------------KG-NLVYIIDFGLAKKFRDARSLKHIPYR 168

Human   205 EDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKM 269
            |:|||||||||||||.|||||||||||:|||||||||||..:|||||||||.|:||||:|||||:
  Fly   169 ENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKL 233

Human   270 STPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLK---- 330
            ||.:.|||||||:||..|||:||.:.|::.|||.:||:|||.||..|...|||.|||.:||
  Fly   234 STSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGP 298

Human   331 --QKAAQQ-----------------------AASSSGQGQQ 346
              .:|.||                       ||:||.|.||
  Fly   299 RNPQAIQQAQDGADGQAGHDAVAAAAAVAAAAAASSHQQQQ 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1A1	NP_001020276.1	STKc_CK1_alpha	16..309	CDD:271030	192/292 (66%)
dco	NP_524602.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	198/301 (66%)