DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSNK1A1 and ball

DIOPT Version :9

Sequence 1:	NP_001020276.1	Gene:	CSNK1A1 / 1452	HGNCID:	2451	Length:	365	Species:	Homo sapiens
Sequence 2:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	377	Identity:	100/377 - (26%)
Similarity:	147/377 - (38%)	Gaps:	71/377 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    15 GKYKLVRKIGSGSFGDIYLAINITNGE---EVAVKLESQKARHPQL------LYESKLYKILQ-- 68
            |::::...||.|.||:||.|..:  ||   :..||.|.. ...|..      |..:||..|.|
  Fly    45 GQWRIGPSIGVGGFGEIYAACKV--GEKNYDAVVKCEPH-GNGPLFVEMHFYLRNAKLEDIKQFM 106

Human    69 -----GGVGIPHIRWYGQ-----EKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 123
                 ..:|:|:|...|.     || :..:||...|..|........:|....||..||.||:..
  Fly   107 QKHGLKSLGMPYILANGSVEVNGEK-HRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDV 170

Human   124 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGL 188
            .:|:|:..::|.|:|..|.|:|:.:                           .|..|.:|:||||
  Fly   171 YQYMHSNGYVHADLKAANILLGLEK---------------------------GGAAQAYLVDFGL 208

Human   189 AK-----KYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLP 248
            |.     .::.:..:.|         .||..|.|.:||||: .:||.|:|.|||.|:.:....||
  Fly   209 ASHFVTGDFKPDPKKMH---------NGTIEYTSRDAHLGV-PTRRADLEILGYNLIEWLGAELP 263

Human   249 WQGLKAATKKQKYEKISEKKMSTPVEVL----CKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
            |...|......|.:|..|..|....|.|    .||.|.....::.|...|...:.|||...|..|
  Fly   264 WVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWF 328

Human   310 RILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSN 361
            ....:.|....:...|:.|..|.::....|..|..:.|.....|:.|....|
  Fly   329 SSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLN 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1A1	NP_001020276.1	STKc_CK1_alpha	16..309	CDD:271030	88/322 (27%)
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	89/323 (28%)
		SPS1	47..432	CDD:223589	99/375 (26%)
		Pol_alpha_B_N	<399..>502	CDD:285602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910