DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSNK1A1 and CkIalpha

DIOPT Version :9

Sequence 1:	NP_001020276.1	Gene:	CSNK1A1 / 1452	HGNCID:	2451	Length:	365	Species:	Homo sapiens
Sequence 2:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	253/358 - (70%)
Similarity:	281/358 - (78%)	Gaps:	36/358 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     7 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71
            |:.|.||||||:::|||||||||||||.::|.:|||||:|:||..|||||||||:|||:||.|||
  Fly    10 SRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGV 74

Human    72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRD 136
            |.|.||.:|:||::|.|||||||||||||||||:|.||:||||||.||||.|:||:|.|.|||||
  Fly    75 GFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRD 139

Human   137 IKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHI 201
            ||||||||||||||||                            |||||||||||:||..||.||
  Fly   140 IKPDNFLMGIGRHCNK----------------------------LFLIDFGLAKKFRDPHTRHHI 176

Human   202 PYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 266
            .||||||||||||||||||||||||||||||||||||:|||||..|||||:||.||:||||||||
  Fly   177 VYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISE 241

Human   267 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ 331
            ||||||:||||||.||||:|||||||.|||||.|||||||||||||||||||||||.:|||||||
  Fly   242 KKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQ 306

Human   332 KAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKG 364
            |        :.|||.......:|.||.|....|
  Fly   307 K--------THQGQPNPAILLEQLDKDKEKQNG 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSNK1A1	NP_001020276.1	STKc_CK1_alpha	16..309	CDD:271030	216/292 (74%)
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	216/292 (74%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	214/288 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159352
Domainoid	1	1.000	372	1.000	Domainoid score	I901
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111694
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1265
Isobase	1	0.950	-	0	Normalized mean entropy	S180
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	1	1.000	-	-		otm40947
orthoMCL	1	0.900	-	-		OOG6_100396
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890