DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNRNPA1L2 and hrpa-1

DIOPT Version :9

Sequence 1:	NP_001011724.1	Gene:	HNRNPA1L2 / 144983	HGNCID:	27067	Length:	320	Species:	Homo sapiens
Sequence 2:	NP_001040945.1	Gene:	hrpa-1 / 177101	WormBaseID:	WBGene00001999	Length:	347	Species:	Caenorhabditis elegans

Alignment Length:	334	Identity:	151/334 - (45%)
Similarity:	198/334 - (59%)	Gaps:	26/334 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     9 EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMN 73
            |||.|||:|:|||:..|||:.:|..:.|:|.:||.:|||||.|||||||||||::...||||||.
Worm    18 EPENLRKIFVGGLTSNTTDDLMREFYSQFGEITDIIVMRDPTTKRSRGFGFVTFSGKTEVDAAMK 82

Human    74 TTPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMT 138
            ..||.:||:.|:|||||.|:|..|..::::.|:::|.|::||..|..|.:||.:||.:...||:.
Worm    83 QRPHIIDGKTVDPKRAVPRDDKNRSESNVSTKRLYVSGVREDHTEDMLTEYFTKYGTVTKSEIIL 147

Human   139 DRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVKGHNCEVRKALPKQEMASA----------SSSQ 193
            |:.:.|.|||.|||||||||||:.|:||.|.|.||.|:|||.|.|.||:.|          ..|:
Worm   148 DKATQKPRGFGFVTFDDHDSVDQCVLQKSHMVNGHRCDVRKGLSKDEMSKAQMNRDRETRGGRSR 212

Human   194 RGRRGSGNFGGGRGDGFGGNDNFGRGGNFSGRGGFG-GSCGGGGYGG-----SGDGYNGFGNDGS 252
            .|:||..|.|||.|.|:||....|..|.:.|.||.| |..|||.|||     .|.|..|:|....
Worm   213 DGQRGGYNGGGGGGGGWGGPAQRGGPGAYGGPGGGGQGGYGGGNYGGGWGQQGGGGQGGWGGPQQ 277

Human   253 NFGGGGSYNDFGNYNNQSSNFGP--MKGGNFGGRSSGPYGGGGQYFAKPQNQGGYGVSSSSSSY- 314
            ..||||.....|  ..|....||  .:.|.:||...|  ||||.:..:.|.|||:|..|.:..:
Worm   278 QQGGGGWGQQGG--GGQGGWGGPQQQQQGGWGGPQQG--GGGGGWGGQGQQQGGWGGQSGAQQWA 338

Human   315 ---GSGRRF 320
               |..|.:
Worm   339 HAQGGNRNY 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1L2	NP_001011724.1	Globular A domain	4..94		51/84 (61%)
		RRM1_hnRNPA1	12..92	CDD:410154	47/79 (59%)
		Globular B domain	95..185		43/89 (48%)
		RRM_SF	105..184	CDD:418427	41/78 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..216		17/44 (39%)
		RNA-binding RGG-box	218..240		12/27 (44%)
		HnRNPA1	255..292	CDD:402981	13/38 (34%)
		Nuclear targeting sequence. /evidence=ECO:0000250	268..305		14/38 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..320		18/54 (33%)
hrpa-1	NP_001040945.1	RRM1_hnRNPA_like	24..101	CDD:241022	45/76 (59%)
hrpa-1	NP_001040945.1	RRM2_hnRNPA_like	115..187	CDD:240774	36/71 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I6437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I1815
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.880