DRSC/TRiP Functional Genomics Resources

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Protein Alignment FBXL14 and FipoQ

DIOPT Version :10

Sequence 1:NP_689654.1 Gene:FBXL14 / 144699 HGNCID:28624 Length:418 Species:Homo sapiens
Sequence 2:NP_733291.1 Gene:FipoQ / 43475 FlyBaseID:FBgn0039667 Length:515 Species:Drosophila melanogaster


Alignment Length:511 Identity:112/511 - (21%)
Similarity:189/511 - (36%) Gaps:147/511 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     2 ETHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQ 66
            :|.|..|..::|..||.||..|:..|.|::|..||..||...:|:           |.||.|.:.
  Fly    31 DTTIEKLPDKVLLHIFSYLSHREICRLARICRRWRQIAYDTRLWK-----------NVSLRPEVS 84

Human    67 ARGI----RRVQILSLR--RSLSYV---IQGMANIESLNLSG-CYNLTDNGLGHAFVQEI----- 116
            ...:    ..:|::|:|  .:|.|:   |:.:.:.....||. |.|||...|..:...::     
  Fly    85 GLHVGSLEMLLQLISVRFGPTLRYIELPIELITHTVLHELSAKCPNLTHMLLDFSTAMQLHDFSE 149

Human   117 -----GSLRALNLSLCKQI-TDSSLGRIAQYLKGLEVLELGG----CS-------NITNTGLLLI 164
                 ..||.:.:.|.:.| .:..:.:|..::.|||||.|.|    |.       .:.|...|..
  Fly   150 MQAFPTKLRYMCVCLSEVIFMEGFMRKIYNFINGLEVLHLIGTYEKCEEEEEEIYEVINVHKLKS 214

Human   165 AWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHI---SRG 226
            |  ...|:.:||.....:.|   .|:...    :..|:.||.|.:..|.|:|..:||.:   |:.
  Fly   215 A--TPNLRVINLYGINFIDD---SHIDAF----SSNCIQLECLAVNFCNKVTGSTLKTLIQRSKR 270

Human   227 LT-----------------------------------------------GLRLLNLSFCGGISDA 244
            ||                                               .|:.|:.....|.:|:
  Fly   271 LTCLLMNGTSLKSEFVMQAEWDKCALQELDITATDLSTECLVDMLSRIPSLKFLSAGQINGFNDS 335

Human   245 GLLHLSHMG---SLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDG 306
            .|......|   ||.||:|.|.|||||.|::              .|..:.|.|..|....|:. 
  Fly   336 VLKQWMESGTTRSLISLDLDSSDNISDEGLL--------------KFIQRQGHQLSACCLSGMP- 385

Human   307 LKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRI-----TDKGLELIAEHLSQLTGIDL--- 363
                     ||:|.....::..:...:.:.:|...::     .|:.::.||.:...|..::|   
  Fly   386 ---------HITDQLWMSILPLLGNCKIIVMGTAEKLGVNIHVDQLMDTIASNCGNLERLELRWD 441

Human   364 ---YGCTRITKRGLERITQLPCLK----VLNLGLWQMTDSEKEARGDFSPLFTVRT 412
               ...:..:::.:: |.::.|||    ||:.|.:..|......|.|  .:..|||
  Fly   442 PDNLRFSDKSQKAID-ILRVKCLKLRCMVLSDGRYYETVKANFERAD--RITVVRT 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FBXL14NP_689654.1 Required for down-regulation of SNAI1 2..48 17/45 (38%)
F-box_FBXL14 6..46 CDD:438897 14/39 (36%)
AMN1 90..296 CDD:187754 60/281 (21%)
leucine-rich repeat 92..118 CDD:275381 7/36 (19%)
leucine-rich repeat 119..142 CDD:275381 5/23 (22%)
LRR 1 144..163 9/29 (31%)
leucine-rich repeat 145..170 CDD:275381 10/35 (29%)
LRR 2 170..191 5/20 (25%)
leucine-rich repeat 171..203 CDD:275381 6/31 (19%)
LRR 3 203..225 8/24 (33%)
leucine-rich repeat 204..229 CDD:275381 11/74 (15%)
AMN1 228..401 CDD:187754 41/237 (17%)
LRR 4 229..250 5/20 (25%)
leucine-rich repeat 230..254 CDD:275381 6/26 (23%)
LRR 5 254..275 12/20 (60%)
leucine-rich repeat 255..280 CDD:275381 11/24 (46%)
leucine-rich repeat 281..306 CDD:275381 5/24 (21%)
leucine-rich repeat 307..331 CDD:275381 3/23 (13%)
leucine-rich repeat 332..357 CDD:275381 4/29 (14%)
leucine-rich repeat 358..382 CDD:275381 3/29 (10%)
FipoQNP_733291.1 F-box-like 34..78 CDD:463757 17/54 (31%)
ING 110..>166 CDD:355795 11/55 (20%)
leucine-rich repeat 131..156 CDD:275381 3/24 (13%)
leucine-rich repeat 157..175 CDD:275381 4/17 (24%)
leucine-rich repeat 219..244 CDD:275381 6/31 (19%)
leucine-rich repeat 245..270 CDD:275381 9/24 (38%)
leucine-rich repeat 271..295 CDD:275381 2/23 (9%)
leucine-rich repeat 296..320 CDD:275381 0/23 (0%)
leucine-rich repeat 321..348 CDD:275381 6/26 (23%)
leucine-rich repeat 349..375 CDD:275381 13/39 (33%)
leucine-rich repeat 376..403 CDD:275381 5/36 (14%)

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