Protein Alignment FBXL14 and Ppa

DIOPT Version :10

• Sequence 1: NP_689654.1
• Gene: FBXL14 / 144699
• HGNCID: 28624
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_001261138.1
• Gene: Ppa / 37602
• FlyBaseID: FBgn0020257
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 413
• Identity: 249/413 - (60%)
• Similarity: 316/413 - (76%)
• Gaps: 10/413 - (2%)

Human     3 THISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQA 67
            ||||.||||||..||.:|.|||.|||||||||||||||.||||:||||||||:|::||||..|..
  Fly   147 THISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVK 211

Human    68 RGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITD 132
            |||::||||||||||..::.|:..:.|||||||:|:.|..|||||..::.:|:.|:|||||||||
  Fly   212 RGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADMNLGHAFSVDLPNLKTLDLSLCKQITD 276

Human   133 SSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSA 197
            :|||||||:|:.||.||||||.||||||||||||||::||.||||||.|:||.|||||||.:|..
  Fly   277 TSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRET 341

Human   198 AEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRS 262
            |||.|.||.|.|||||:|:|.:|.||::|||.|:.:|||||..::|:||.||:.|..|..|||||
  Fly   342 AEGNLQLEYLGLQDCQRLSDEALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRS 406

Human   263 CDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVR 327
            ||||||.|:.:|..|...::.||||||||:.||:|.:|||||..|:||||..|.|:|.|:.::.:
  Fly   407 CDNISDIGMAYLTEGGSGINSLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAK 471

Human   328 QMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ 392
            .:|.|..||||||.|||||||:.:||.|:.|..|||||||:::.:|::.|.:||.|:.||||||.
  Fly   472 ALHELENLNIGQCSRITDKGLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPKLQKLNLGLWL 536

Human   393 MTD----------SEKEARGDFS 405
            :..          :::.|||.::
  Fly   537 VRXCVHHDCNACAAKEAARGSYN 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXL14	NP_689654.1	Required for down-regulation of SNAI1	2..48		35/44 (80%)
		F-box_FBXL14	6..46	CDD:438897	31/39 (79%)
		AMN1	90..296	CDD:187754	130/205 (63%)
		leucine-rich repeat	92..118	CDD:275381	14/25 (56%)
		leucine-rich repeat	119..142	CDD:275381	18/22 (82%)
		LRR 1	144..163		15/18 (83%)
		leucine-rich repeat	145..170	CDD:275381	22/24 (92%)
		LRR 2	170..191		15/20 (75%)
		leucine-rich repeat	171..203	CDD:275381	22/31 (71%)
		LRR 3	203..225		13/21 (62%)
		leucine-rich repeat	204..229	CDD:275381	15/24 (63%)
		AMN1	228..401	CDD:187754	90/182 (49%)
		LRR 4	229..250		10/20 (50%)
		leucine-rich repeat	230..254	CDD:275381	12/23 (52%)
		LRR 5	254..275		13/20 (65%)
		leucine-rich repeat	255..280	CDD:275381	15/24 (63%)
		leucine-rich repeat	281..306	CDD:275381	16/24 (67%)
		leucine-rich repeat	307..331	CDD:275381	9/23 (39%)
		leucine-rich repeat	332..357	CDD:275381	17/24 (71%)
		leucine-rich repeat	358..382	CDD:275381	11/23 (48%)
Ppa	NP_001261138.1	F-box_FBXL14	150..190	CDD:438897	31/39 (79%)
		AMN1	<226..>334	CDD:187754	71/107 (66%)
		leucine-rich repeat	236..256	CDD:275381	12/19 (63%)
		leucine-rich repeat	263..288	CDD:275381	19/24 (79%)
		leucine-rich repeat	289..314	CDD:275381	22/24 (92%)
		leucine-rich repeat	315..347	CDD:275381	22/31 (71%)
		AMN1	347..524	CDD:187754	96/176 (55%)
		leucine-rich repeat	348..373	CDD:275381	15/24 (63%)
		leucine-rich repeat	374..398	CDD:275381	12/23 (52%)
		leucine-rich repeat	399..424	CDD:275381	15/24 (63%)
		leucine-rich repeat	425..450	CDD:275381	16/24 (67%)
		leucine-rich repeat	451..475	CDD:275381	9/23 (39%)
		leucine-rich repeat	476..501	CDD:275381	17/24 (71%)