Protein Alignment FBXL14 and Fbl6

DIOPT Version :10

• Sequence 1: NP_689654.1
• Gene: FBXL14 / 144699
• HGNCID: 28624
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_610665.2
• Gene: Fbl6 / 36201
• FlyBaseID: FBgn0033609
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 89/429 - (20%)
• Similarity: 176/429 - (41%)
• Gaps: 87/429 - (20%)

Human    11 ELLAMIFGYLDVRDKG------RAAQVCTAWRDAAYHKSVWRGVE----------AKLHLRRANP 59
            |:|..||.:. |..:|      |..:||:.||..:...::||.::          .:|.|:....
  Fly   296 EVLFRIFEHA-VDTQGCLPTLFRLGRVCSLWRQVSLRPTLWRTMDLTTWVKEKYRTELKLKWFVD 359

Human    60 SLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNL 124
            :...:.....:...:|..:...|:.:..|..|:..:.|||....|.:.|.: .|..:..|:.|:|
  Fly   360 NRCSACTDLNVSNWKISDINCFLAKLSSGCPNLAGITLSGWKGFTSDHLTY-LVDNMHKLQRLDL 423

Human   125 -----------------SLCK--QITDSSL-----------------GRIAQYLKGLEVLELGGC 153
                             |||.  |...|.|                 |.::.:...|.:|:|
  Fly   424 SSINVEMNASKSAVGVNSLCNALQTMGSRLTHLYLAHNRLAGIPQIVGILSTHCPNLTLLDL--- 485

Human   154 SNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGI--GHLAGMTRSAAE-----GCLGLEQLTL-- 209
            ||:|...   .:.|:..::.|. |.|:.|..:.:  .|:...|.|..|     |...||:|::
  Fly   486 SNVTTQA---TSHGVLHIEKLQ-RGCQKLKVLRVTNSHITPSTASMQEIMDSPGFPELEELSVAA 546

Human   210 --QDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGI- 271
              .:.:.::|..|:.|.:..:.|:||::..|..::...|:.|. ...::.|.|..|....|.|.
  Fly   547 LTDESRIISDDHLQRILKSSSKLKLLDVRNCTRLTHESLIRLP-AWDIKHLFLSGCSVTRDMGSG 610

Human   272 --MHLAMGSLRLSGLDVSFCD--KVGDQSLAYIAQ-GLDG-LKSLSLCSCHISDDGINRMVRQMH 330
              :..:..:..|..||:::.:  :..|.:|..:|: |.|. |..|:||...:||:.:..::....
  Fly   611 LELIASKWAHSLIELDLAWANMQQPIDNALRALAEKGRDSPLAHLNLCGSSVSDEAVKEILTNCQ 675

Human   331 GLRTLNIGQCVRITDKGLELIAE------HLSQLTGIDL 363
            .:.::|:..| |...:|::.:.:      .|.::.|:.|
  Fly   676 NMSSINLASC-RGLPRGVKRLMQGPQELGELREVLGVQL 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXL14	NP_689654.1	Required for down-regulation of SNAI1	2..48		13/42 (31%)
		F-box_FBXL14	6..46	CDD:438897	11/40 (28%)
		AMN1	90..296	CDD:187754	54/257 (21%)
		leucine-rich repeat	92..118	CDD:275381	6/25 (24%)
		leucine-rich repeat	119..142	CDD:275381	10/58 (17%)
		LRR 1	144..163		6/18 (33%)
		leucine-rich repeat	145..170	CDD:275381	7/24 (29%)
		LRR 2	170..191		5/22 (23%)
		leucine-rich repeat	171..203	CDD:275381	9/38 (24%)
		LRR 3	203..225		6/25 (24%)
		leucine-rich repeat	204..229	CDD:275381	6/28 (21%)
		AMN1	228..401	CDD:187754	32/149 (21%)
		LRR 4	229..250		5/20 (25%)
		leucine-rich repeat	230..254	CDD:275381	6/23 (26%)
		LRR 5	254..275		5/23 (22%)
		leucine-rich repeat	255..280	CDD:275381	5/27 (19%)
		leucine-rich repeat	281..306	CDD:275381	7/27 (26%)
		leucine-rich repeat	307..331	CDD:275381	6/23 (26%)
		leucine-rich repeat	332..357	CDD:275381	5/30 (17%)
		leucine-rich repeat	358..382	CDD:275381	2/6 (33%)
Fbl6	NP_610665.2	PLN03237	<3..254	CDD:215641
		F-box_FBXL6	291..336	CDD:438891	11/40 (28%)
		leucine-rich repeat	365..391	CDD:275381	3/25 (12%)
		LRR	<366..>521	CDD:443914	32/162 (20%)
		leucine-rich repeat	392..417	CDD:275381	6/25 (24%)
		leucine-rich repeat	418..445	CDD:275381	6/26 (23%)
		leucine-rich repeat	453..471	CDD:275381	1/17 (6%)
		leucine-rich repeat	480..509	CDD:275381	10/35 (29%)
		leucine-rich repeat	510..538	CDD:275381	6/27 (22%)
		leucine-rich repeat	539..579	CDD:275381	10/39 (26%)
		leucine-rich repeat	580..621	CDD:275381	7/41 (17%)
		leucine-rich repeat	622..649	CDD:275381	7/26 (27%)
		leucine-rich repeat	652..676	CDD:275381	6/23 (26%)
		leucine-rich repeat	677..698	CDD:275381	4/21 (19%)