DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gata5 and pnr

DIOPT Version :9

Sequence 1:	NP_032119.2	Gene:	Gata5 / 14464	MGIID:	109497	Length:	404	Species:	Mus musculus
Sequence 2:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	149/392 - (38%)
Similarity:	197/392 - (50%)	Gaps:	94/392 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 YQSLALAQSPGQGTYADSGAFLHSSGTGSPVFVAPTRMPSMLPYLPSCEPGSQAPALAAHSSWTQ 66
            ||::.|           |.|...:|.:.|...||..:|             ..:.|:||::....
  Fly    27 YQNVTL-----------SAASASTSASASATHVAAVKM-------------YHSSAVAAYTDLAA 67

Mouse    67 AVAADSSAFGSG--SPHPPAAHPPGATTFPFAHSPPG------SGSGGSAGVRDGGAFQGALLAR 123
            |.:|.|:..|.|  ..|..|.:.|       .:.|..      :...|||..::....:|...|.
  Fly    68 AGSAASAGVGVGVSGYHQQAVNAP-------VYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAH 125

Mouse   124 EQYPTPLGRPMGASYPTTYPAYMSSDVAPSWTSGAFDSSILHGLQARPGGLPGRRTSFVPDFLEE 188
            .|:.:|....|..|:.:.|      |.:....|..::|::                    ||  :
  Fly   126 AQFYSPNAAVMMGSWRSAY------DPSGFQRSSPYESAM--------------------DF--Q 162

Mouse   189 FPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRL---SSSRRSGLCC 250
            | |||||||||||:||||||||||||||||||||||||||:||||::|.|||   :::||.||||
  Fly   163 F-GEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCC 226

Mouse   251 SNCHTATTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNPAKIKGSSGSTA 315
            :||.|.||||||||::|||||||||||.|||||.|||||:|:.|||||||||     |..|||..
  Fly   227 TNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPK-----KTGSGSAV 286

Mouse   316 NTTASSPTLLNSESSATTLKAESSLASPVCAGPTITSQASSPADESLASSHLEFKFEPEDFAFTS 380
            .....|.|       .:||:|...........|:::.:.     .||:..|.:.|      :.||
  Fly   287 GAGTGSGT-------GSTLEAIKECKEEHDLKPSLSLER-----HSLSKLHTDMK------SGTS 333

Mouse   381 SS 382
            ||
  Fly   334 SS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gata5	NP_032119.2	GATA-N	1..181	CDD:368398	35/186 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..112		10/48 (21%)
		ZnF_GATA	195..239	CDD:238123	38/43 (88%)
		ZnF_GATA	250..300	CDD:238123	39/49 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..332		15/38 (39%)
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	42/47 (89%)
		ZnF_GATA	168..212	CDD:238123	38/43 (88%)
		ZnF_GATA	223..270	CDD:214648	37/46 (80%)
		ZnF_GATA	226..276	CDD:238123	39/49 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832214
Domainoid	1	1.000	81	1.000	Domainoid score	I8484
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3460
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm42631
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	1	1.000	-	-		X1091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.880