DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gata4 and pnr

DIOPT Version :9

Sequence 1:	NP_001297539.1	Gene:	Gata4 / 14463	MGIID:	95664	Length:	442	Species:	Mus musculus
Sequence 2:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	158/416 - (37%)
Similarity:	207/416 - (49%)	Gaps:	78/416 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 GAYEAGGPGAFMHSAGAASSPVYVPTPRV--PSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGA 78
            |.|:.....|...|..|::|..:|...::  .|:|...:.|...||||:||.      |.|.|
  Fly    25 GDYQNVTLSAASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGV------GVGVS-- 81

Mouse    79 GPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGL 143
                     |:.|.......|.|   |.|     ....:||...:|||:.|
  Fly    82 ---------GYHQQAVNAPVYVP---SNR-----QYNHVAAHFGSAAAQNA-------------- 115

Mouse   144 AGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLVDMF 208
                 :...||..:::..|....|.:..||.:|...|.....||             :.:.:|.
  Fly   116 -----WTTEGFGSAHAQFYSPNAAVMMGSWRSAYDPSGFQRSSP-------------YESAMDF- 161

Mouse   209 DDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRL---SASRRVGLS 270
             .|.||||||||||:||||||||||||||||||||||||||:|||||||.:||   :|:||:||.
  Fly   162 -QFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLC 225

Mouse   271 CANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPA 335
            |.||.|.||||||||.:|||||||||||.|||||.|||||||:||||||||||     ||.:|.|
  Fly   226 CTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPK-----KTGSGSA 285

Mouse   336 GETLPPSSGASSGNSSNATSSSSSSEEMRPIKT--EPGLSSHYGHSSSMSQTFSTVSGHGPSIHP 398
               :...:|:.:|::..|........:::|..:  ...||..:....|.:.:.||:.||    |.
  Fly   286 ---VGAGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGH----HS 343

Mouse   399 VLSALKLSPQGYASPVTQTSQASSKQ 424
            .....:...|.......|..|::.:|
  Fly   344 AQQQQQQQQQQQQQQQQQQQQSAHQQ 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gata4	NP_001297539.1	GATA-N	1..204	CDD:368398	41/189 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..107		12/46 (26%)
		ZnF_GATA	216..266	CDD:238123	43/52 (83%)
		ZnF_GATA	270..321	CDD:238123	41/50 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..393		24/80 (30%)
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	43/47 (91%)
		ZnF_GATA	168..212	CDD:238123	40/43 (93%)
		ZnF_GATA	223..270	CDD:214648	37/46 (80%)
		ZnF_GATA	226..276	CDD:238123	41/49 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8484
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3460
Isobase	1	0.950	-	0	Normalized mean entropy	S2600
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm42631
orthoMCL	1	0.900	-	-		OOG6_105861
Panther	1	1.100	-	-	LDO	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	1	1.000	-	-		X1091
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.800