DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and Adgrl2

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_036019331.1	Gene:	Adgrl2 / 99633	MGIID:	2139714	Length:	1494	Species:	Mus musculus

Alignment Length:	1071	Identity:	180/1071 - (16%)
Similarity:	331/1071 - (30%)	Gaps:	411/1071 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 CYGSNIIAMDLQNF-----ELSKVSQFLKKMNISDFWLPIRRNDELMPYEVRLPGKSWRKEINRS 185
            |.||::|.::..|:     ::.....|  :|..:|.:||                     :..:.
Mouse    51 CPGSDVIMIESANYGRTDDKICDADPF--QMENTDCYLP---------------------DAFKI 92

  Fly   186 LIHLQNNPNEHCLKHT----INNQTPADFKSQIVSVDC----------------NAFLNAVCIFK 230
            :....||..: |:..|    ..:..|..:|...|..:|                .|.:::.||::
Mouse    93 MTQRCNNRTQ-CIVVTGSDVFPDPCPGTYKYLEVQYECVPYKVEQKVFVCPGTLKAIVDSPCIYE 156

  Fly   231 SELISNAGCPSGFGALVYQPAVCYGIDWNNTTYEPLDLKEYLKKRNWLRRILAKYVLKKNRHEFF 295
            :|..|.|.|.                       :||...:.:....|..               :
Mouse   157 AEQKSGAWCK-----------------------DPLQAADKIYFMPWTP---------------Y 183

  Fly   296 KIDFFIHHSTKMEYVIKMSLSEDFQIVSKGLKWIPTLSKQIVKSSSAVEMVLEIDHRSKGVRLVI 360
            :.|      |.:||.   || ||||                   :|......::.:|..|...|:
Mouse   184 RTD------TLIEYA---SL-EDFQ-------------------NSRQTTTYKLPNRVDGTGFVV 219

  Fly   361 YNRKYLWKNNNSYVGVKCFALLKYGTLKNVRLDLIWENQEQSYSILKVNIVSSYRTEYWCEGHSI 425
            |:                              ..::.|:|::.:|:|.::.:..::     |.:|
Mouse   220 YD------------------------------GAVFFNKERTRNIVKFDLRTRIKS-----GEAI 249

  Fly   426 FEFQ------------LVSTRLFVDVNRSIAPVFVLRWN-----VSCINANFAYNLCDEVT---- 469
            ..:.            .....|.||.| .:..::....|     :|.:|   .|.|..|.|
Mouse   250 INYANYHDTSPYRWGGKTDIDLAVDEN-GLWVIYATEQNNGMIVISQLN---PYTLRFEATWETA 310

  Fly   470 -DKNLRK----------LIESVY-------GNNNLGNLLIYDVRIMNIEWIKNMCVVFWIHITAT 516
             ||....          ::.|||       |.|.:.  .||:.|:...|::.   |.|
Mouse   311 YDKRAASNAFMICGVLYVVRSVYQDNESEAGKNTID--YIYNTRLSRGEYVD---VPF------- 363

  Fly   517 LKSTASTYHKEIAFVDNTPRIPKDFVAFMKVKITLSNFFLNF------------------IKNST 563
                 ...::.||.||..||..:.:|       ..:||.|.:                  |.:|.
Mouse   364 -----PNQYQYIAAVDYNPRDNQLYV-------WNNNFILRYSLEFGPPDPAQVPTTAVTITSSA 416

  Fly   564 YLLRSTDYCFSELS----------FSNDGMHLWWTTTRIGEIAMTKKLCIQKDGMPYT------- 611
            .|.::|....|..|          ...||..    .|:......|.|:      .|.|
Mouse   417 ELFKTTISTTSSASQRGPVSSTAAGPQDGSR----GTKPPPAVSTTKI------PPVTNIFPLPE 471

  Fly   612 RLCLGDFVHGAYWKKLTQPVVCESP-----KNNTKVL------------HDL---------QVAK 650
            |.|......|..|.:..:.::.|.|     :.....|            .||         |:|:
Mouse   472 RFCEALDWKGIKWPQTQRGMMVERPCPKGTRGTASYLCMASTGTWNPKGPDLSNCTSHWVNQLAQ 536

  Fly   651 MFKSPPEKVLKYLKDIIANSKNSIVPADIFLIYKIFQSVHEI----------------HSSNSEF 699
            ..:| .|.......::..::|..:...|:....::.:.:.:|                ..|.::.
Mouse   537 KIRS-GENAASLANELAKHTKGHVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKL 600

  Fly   700 QQTTKDLTNWKNAIYEIFDIYNVLIGLDSKVIKMSAELNATNMFLKSFEMLFDTLSLNNLSFTQI 764
            |:..|....:..||.:..|  |:   |.::.::....:|::.. ..:..||.|||...  :|...
Mouse   601 QKREKTCRAYLKAIVDTVD--NL---LRAEALESWKHMNSSEQ-AHTATMLLDTLEEG--AFVLA 657

  Fly   765 DNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIANV-------------SGIALFANNN 816
            ||..|...             ||:.....:|..:::.:...|             |.|.|.||..
Mouse   658 DNLLEPTR-------------VSMPTENIVLEVAVLSTEGQVQDFKFPLGLKGLGSSIQLSANTV 709

  Fly   817 KKNTPTKLKGAFKNEHYRFLQVNHNINDVVNEPDLELAAYLPI-ELIDTLQASTNKTNDVIVVIK 880
            |:|:...|                        ..|....|..: :.:.|..|:.....|::
Mouse   710 KQNSRNGL------------------------AKLVFIIYRSLGQFLSTENATIKLGADLM---- 746

  Fly   881 VYSNDELFQQSVRNLTLL--SRVVSISLPGYSSFLPVPVPLIFRKSKNKKVNPP----GSCLVWN 939
                       .||.|:.  |.|:|:|:...||.:.:..|::|..   ..::|.    .:|..||
Mouse   747 -----------GRNSTIAVNSPVISVSINKESSRVYLTDPVLFTL---PHIDPDNYFNANCSFWN 797

  Fly   940 YEGWIDGYSMLSYF--------ENNEGIALCRLRRLAPTGYFL-EKKISIENHIINHDLRMSNTK 995
            |    ...:|:.|:        :.|:....|....|......: .::|:.::.:  |.|.::...
Mouse   798 Y----SERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGV--HHLLLTVIT 856

  Fly   996 LNGNIIYVILLSCCILMFIGFLFCKCIFRRL 1026
            ..|.::.::.|:.||..|       |.||.|
Mouse   857 WVGIVVSLVCLAICIFTF-------CFFRGL 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
Adgrl2	XP_036019331.1	Gal_Lectin	49..129	CDD:396628	17/101 (17%)
		OLF	143..399	CDD:413369	65/385 (17%)
		HormR	470..534	CDD:214468	9/63 (14%)
		GAIN	543..765	CDD:406802	45/281 (16%)
		GPS	789..841	CDD:197639	9/55 (16%)
		7tm_GPCRs	850..1130	CDD:421689	10/38 (26%)
		TM helix 1	851..876	CDD:410628	5/31 (16%)
		TM helix 2	885..907	CDD:410628
		TM helix 3	916..943	CDD:410628
		TM helix 4	955..975	CDD:410628
		TM helix 5	992..1021	CDD:410628
		TM helix 6	1037..1088	CDD:410628
		TM helix 7	1092..1117	CDD:410628
		Latrophilin	1129..1494	CDD:396778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910